Dendroamides, new cyclic hexapeptides from a blue-green alga. Multidrug- resistance reversing activity of dendroamide A

Junichi Ogino; Richard E. Moore; Gregory M.L. Patterson; Charles D. Smith

doi:10.1021/np960178s

Dendroamides, new cyclic hexapeptides from a blue-green alga. Multidrug- resistance reversing activity of dendroamide A

Junichi Ogino, Richard E. Moore, Gregory M.L. Patterson, Charles D. Smith

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

Dendroamide A (1), one of three new bistratamide-type cyclic hexapeptides from the terrestrial blue-green alga (cyanobacterium) Stigonema dendroideum Fremy, exhibits multidrug-resistance reversing activity. The gross structures of the three compounds, dendroamides A-C, were determined by NMR and mass spectral analyses. Their absolute stereochemistries were determined by Marfey and chiral GC/MS analyses of derivatives formed from acid hydrolysis of the intact and ozonized peptides.

Original language	English (US)
Pages (from-to)	581-586
Number of pages	6
Journal	Journal of Natural Products
Volume	59
Issue number	6
DOIs	https://doi.org/10.1021/np960178s
State	Published - Jun 1996

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np960178s

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abstract = "Dendroamide A (1), one of three new bistratamide-type cyclic hexapeptides from the terrestrial blue-green alga (cyanobacterium) Stigonema dendroideum Fremy, exhibits multidrug-resistance reversing activity. The gross structures of the three compounds, dendroamides A-C, were determined by NMR and mass spectral analyses. Their absolute stereochemistries were determined by Marfey and chiral GC/MS analyses of derivatives formed from acid hydrolysis of the intact and ozonized peptides.",

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year = "1996",

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AU - Moore, Richard E.

AU - Patterson, Gregory M.L.

AU - Smith, Charles D.

PY - 1996/6

Y1 - 1996/6

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AB - Dendroamide A (1), one of three new bistratamide-type cyclic hexapeptides from the terrestrial blue-green alga (cyanobacterium) Stigonema dendroideum Fremy, exhibits multidrug-resistance reversing activity. The gross structures of the three compounds, dendroamides A-C, were determined by NMR and mass spectral analyses. Their absolute stereochemistries were determined by Marfey and chiral GC/MS analyses of derivatives formed from acid hydrolysis of the intact and ozonized peptides.

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Dendroamides, new cyclic hexapeptides from a blue-green alga. Multidrug- resistance reversing activity of dendroamide A

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