TY - JOUR
T1 - Depression, anxiety, and self-directed violence in women with endometriosis
T2 - A retrospective matched-cohort study
AU - Estes, Stephanie J.
AU - Huisingh, Carrie E.
AU - Chiuve, Stephanie E.
AU - Petruski-Ivleva, Natalia
AU - Missmer, Stacey A.
N1 - Funding Information:
Author affiliations: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Hershey Medical Center, Penn State Health, Hershey, Pennsylvania (Stephanie J. Estes); Global Epidemiology, Pharmacovigilance and Patient Safety, AbbVie, Inc., North Chicago, Illinois, United States (Carrie E. Huisingh, Stephanie E. Chiuve); Aetion, Inc., New York, New York, United States (Natalia Petruski-Ivleva); Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, United States (Stacey A. Missmer); and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States (Stacey A. Missmer). This work was funded by AbbVie, Inc. Presented at the International Conference on Pharmacoepidemiology & Therapeutic Risk Management, August 24–28, 2019, Philadelphia, Pennsylvania. Conflict of interest: AbbVie participated in the study design, research, analysis and interpretation of data, writing, reviewing, and approving the publication. C.E.H. and S.E.C. are employees of AbbVie and receive stock and/or stock options. N.P.-I. is an employee of and holds stock in Aetion, Inc. S.J.E. and S.A.M. conducted this work as paid consultants to AbbVie but did not receive payment for authorship.
Publisher Copyright:
© 2021 The Author(s).
PY - 2021
Y1 - 2021
N2 - The purpose of this study was to compare the incidence of mental health outcomes in women in the United States with and without documented endometriosis. In a retrospective matched-cohort study using administrative health claims data from Optum's Clinformatics DataMart from May 1, 2000, through March 31, 2019, women aged 18-50 years with endometriosis (n = 72,677), identified by International Classification of Disease diagnosis codes (revisions 9 or 10), were matched 1:2 on age and calendar time to women without endometriosis (n = 147,251), with a median follow-up of 529 days (interquartile range, 195, 1,164). The rate per 1,000 person-years of anxiety, depression, and self-directed violence among women with endometriosis was 57.1, 47.7, and 0.9, respectively. Comparing women with endometriosis to those without, the adjusted hazard ratios and 95% confidence intervals were 1.38 (1.34, 1.42) for anxiety, 1.48 (1.44, 1.53) for depression, and 2.03 (1.60, 2.58) for self-directed violence. The association with depression was stronger among women younger than 35 years (P for heterogeneity < 0.01). Risk factors for incident depression, anxiety, and self-directed violence among women with endometriosis included endometriosis-related pain symptoms and prevalence of other chronic conditions associated with pain. The identification of risk factors for mental health conditions among women with endometriosis may improve patient-centered disease management.
AB - The purpose of this study was to compare the incidence of mental health outcomes in women in the United States with and without documented endometriosis. In a retrospective matched-cohort study using administrative health claims data from Optum's Clinformatics DataMart from May 1, 2000, through March 31, 2019, women aged 18-50 years with endometriosis (n = 72,677), identified by International Classification of Disease diagnosis codes (revisions 9 or 10), were matched 1:2 on age and calendar time to women without endometriosis (n = 147,251), with a median follow-up of 529 days (interquartile range, 195, 1,164). The rate per 1,000 person-years of anxiety, depression, and self-directed violence among women with endometriosis was 57.1, 47.7, and 0.9, respectively. Comparing women with endometriosis to those without, the adjusted hazard ratios and 95% confidence intervals were 1.38 (1.34, 1.42) for anxiety, 1.48 (1.44, 1.53) for depression, and 2.03 (1.60, 2.58) for self-directed violence. The association with depression was stronger among women younger than 35 years (P for heterogeneity < 0.01). Risk factors for incident depression, anxiety, and self-directed violence among women with endometriosis included endometriosis-related pain symptoms and prevalence of other chronic conditions associated with pain. The identification of risk factors for mental health conditions among women with endometriosis may improve patient-centered disease management.
UR - http://www.scopus.com/inward/record.url?scp=85105609534&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85105609534&partnerID=8YFLogxK
U2 - 10.1093/aje/kwaa249
DO - 10.1093/aje/kwaa249
M3 - Article
C2 - 33184648
AN - SCOPUS:85105609534
SN - 0002-9262
VL - 190
SP - 843
EP - 852
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 5
ER -