Depression, anxiety, and self-directed violence in women with endometriosis: A retrospective matched-cohort study

Stephanie J. Estes, Carrie E. Huisingh, Stephanie E. Chiuve, Natalia Petruski-Ivleva, Stacey A. Missmer

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The purpose of this study was to compare the incidence of mental health outcomes in women in the United States with and without documented endometriosis. In a retrospective matched-cohort study using administrative health claims data from Optum's Clinformatics DataMart from May 1, 2000, through March 31, 2019, women aged 18-50 years with endometriosis (n = 72,677), identified by International Classification of Disease diagnosis codes (revisions 9 or 10), were matched 1:2 on age and calendar time to women without endometriosis (n = 147,251), with a median follow-up of 529 days (interquartile range, 195, 1,164). The rate per 1,000 person-years of anxiety, depression, and self-directed violence among women with endometriosis was 57.1, 47.7, and 0.9, respectively. Comparing women with endometriosis to those without, the adjusted hazard ratios and 95% confidence intervals were 1.38 (1.34, 1.42) for anxiety, 1.48 (1.44, 1.53) for depression, and 2.03 (1.60, 2.58) for self-directed violence. The association with depression was stronger among women younger than 35 years (P for heterogeneity < 0.01). Risk factors for incident depression, anxiety, and self-directed violence among women with endometriosis included endometriosis-related pain symptoms and prevalence of other chronic conditions associated with pain. The identification of risk factors for mental health conditions among women with endometriosis may improve patient-centered disease management.

Original languageEnglish (US)
Pages (from-to)843-852
Number of pages10
JournalAmerican journal of epidemiology
Volume190
Issue number5
DOIs
StatePublished - 2021

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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