Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction

Hemakesh Mohapatra; Kyle M. Schmid; Scott T. Phillips

doi:10.1039/c2cc17566e

Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction

Hemakesh Mohapatra, Kyle M. Schmid, Scott T. Phillips

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32 Scopus citations

Abstract

This Communication describes three small molecule reagents that amplify the signal for a detection event via an autocatalytic reaction. Two signals are obtained from each reagent: (i) the dibenzofulvene chromophore and (ii) piperidine, which can be visualized using a pH indicator dye. The reagents are demonstrated in a model assay for palladium.

Original language	English (US)
Pages (from-to)	3018-3020
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	24
DOIs	https://doi.org/10.1039/c2cc17566e
State	Published - Feb 22 2012

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc17566e

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title = "Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction",

abstract = "This Communication describes three small molecule reagents that amplify the signal for a detection event via an autocatalytic reaction. Two signals are obtained from each reagent: (i) the dibenzofulvene chromophore and (ii) piperidine, which can be visualized using a pH indicator dye. The reagents are demonstrated in a model assay for palladium.",

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AU - Schmid, Kyle M.

AU - Phillips, Scott T.

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N2 - This Communication describes three small molecule reagents that amplify the signal for a detection event via an autocatalytic reaction. Two signals are obtained from each reagent: (i) the dibenzofulvene chromophore and (ii) piperidine, which can be visualized using a pH indicator dye. The reagents are demonstrated in a model assay for palladium.

AB - This Communication describes three small molecule reagents that amplify the signal for a detection event via an autocatalytic reaction. Two signals are obtained from each reagent: (i) the dibenzofulvene chromophore and (ii) piperidine, which can be visualized using a pH indicator dye. The reagents are demonstrated in a model assay for palladium.

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JO - Chemical Communications

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Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction

Abstract

All Science Journal Classification (ASJC) codes

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