TY - CHAP
T1 - Design Strategies and Applications of Citrate-Based Biodegradable Elastomeric Polymers
AU - Guo, Jinshan
AU - Nguyen, Dianna Y.
AU - Tran, Richard T.
AU - Xie, Zhiwei
AU - Bai, Xiaochun
AU - Yang, Jian
N1 - Funding Information:
This work was supported in part by NSF awards (DMR 1313553 and CMMI 1266116), NIH award (EB012575 and CA182670), and a research award from National Natural Sciences Foundation of China (31228007).
PY - 2014/1
Y1 - 2014/1
N2 - Biodegradable elastomers have recently found numerous applications in diverse areas of biomedical engineering, such as tissue engineering, drug delivery, gene delivery, and bioimaging. In particular, citrate-based biodegradable elastomeric polymers (CABEs) have gained significant attention in recent years. Along with being natural and biocompatible (a Krebs cycle product), citric acid is unique as its multifunctionality confers great freedom in designing a variety of biodegradable polymers with unique physical and chemical properties. This review will discuss the design strategies of CABE polymers and review their applications including cardiovascular, orthopedic, and nerve tissue engineering, bioimaging, tissue adhesives, drug/cell/gene delivery, and endoscopic mucosal resection. It is our hope that this book chapter will provide insightful discussion on previous CABE design, leading to the next innovation of citrate-based biomaterials and biomedical applications.
AB - Biodegradable elastomers have recently found numerous applications in diverse areas of biomedical engineering, such as tissue engineering, drug delivery, gene delivery, and bioimaging. In particular, citrate-based biodegradable elastomeric polymers (CABEs) have gained significant attention in recent years. Along with being natural and biocompatible (a Krebs cycle product), citric acid is unique as its multifunctionality confers great freedom in designing a variety of biodegradable polymers with unique physical and chemical properties. This review will discuss the design strategies of CABE polymers and review their applications including cardiovascular, orthopedic, and nerve tissue engineering, bioimaging, tissue adhesives, drug/cell/gene delivery, and endoscopic mucosal resection. It is our hope that this book chapter will provide insightful discussion on previous CABE design, leading to the next innovation of citrate-based biomaterials and biomedical applications.
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U2 - 10.1016/B978-0-12-396983-5.00017-X
DO - 10.1016/B978-0-12-396983-5.00017-X
M3 - Chapter
AN - SCOPUS:84902943046
SN - 9780123969835
SP - 259
EP - 285
BT - Natural and Synthetic Biomedical Polymers
PB - Elsevier Inc.
ER -