Design Strategies and Applications of Citrate-Based Biodegradable Elastomeric Polymers

Jinshan Guo; Dianna Y. Nguyen; Richard T. Tran; Zhiwei Xie; Xiaochun Bai; Jian Yang

doi:10.1016/B978-0-12-396983-5.00017-X

Design Strategies and Applications of Citrate-Based Biodegradable Elastomeric Polymers

Jinshan Guo
, Dianna Y. Nguyen
, Richard T. Tran
, Zhiwei Xie
, Xiaochun Bai
, Jian Yang

Materials Research Institute (MRI)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

11 Scopus citations

Abstract

Biodegradable elastomers have recently found numerous applications in diverse areas of biomedical engineering, such as tissue engineering, drug delivery, gene delivery, and bioimaging. In particular, citrate-based biodegradable elastomeric polymers (CABEs) have gained significant attention in recent years. Along with being natural and biocompatible (a Krebs cycle product), citric acid is unique as its multifunctionality confers great freedom in designing a variety of biodegradable polymers with unique physical and chemical properties. This review will discuss the design strategies of CABE polymers and review their applications including cardiovascular, orthopedic, and nerve tissue engineering, bioimaging, tissue adhesives, drug/cell/gene delivery, and endoscopic mucosal resection. It is our hope that this book chapter will provide insightful discussion on previous CABE design, leading to the next innovation of citrate-based biomaterials and biomedical applications.

Original language	English (US)
Title of host publication	Natural and Synthetic Biomedical Polymers
Publisher	Elsevier Inc.
Pages	259-285
Number of pages	27
ISBN (Print)	9780123969835
DOIs	https://doi.org/10.1016/B978-0-12-396983-5.00017-X
State	Published - Jan 2014

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-396983-5.00017-X

Cite this

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title = "Design Strategies and Applications of Citrate-Based Biodegradable Elastomeric Polymers",

abstract = "Biodegradable elastomers have recently found numerous applications in diverse areas of biomedical engineering, such as tissue engineering, drug delivery, gene delivery, and bioimaging. In particular, citrate-based biodegradable elastomeric polymers (CABEs) have gained significant attention in recent years. Along with being natural and biocompatible (a Krebs cycle product), citric acid is unique as its multifunctionality confers great freedom in designing a variety of biodegradable polymers with unique physical and chemical properties. This review will discuss the design strategies of CABE polymers and review their applications including cardiovascular, orthopedic, and nerve tissue engineering, bioimaging, tissue adhesives, drug/cell/gene delivery, and endoscopic mucosal resection. It is our hope that this book chapter will provide insightful discussion on previous CABE design, leading to the next innovation of citrate-based biomaterials and biomedical applications.",

author = "Jinshan Guo and Nguyen, \{Dianna Y.\} and Tran, \{Richard T.\} and Zhiwei Xie and Xiaochun Bai and Jian Yang",

note = "Funding Information: This work was supported in part by NSF awards (DMR 1313553 and CMMI 1266116), NIH award (EB012575 and CA182670), and a research award from National Natural Sciences Foundation of China (31228007). ",

year = "2014",

month = jan,

doi = "10.1016/B978-0-12-396983-5.00017-X",

language = "English (US)",

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booktitle = "Natural and Synthetic Biomedical Polymers",

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AU - Guo, Jinshan

AU - Nguyen, Dianna Y.

AU - Tran, Richard T.

AU - Xie, Zhiwei

AU - Bai, Xiaochun

AU - Yang, Jian

N1 - Funding Information: This work was supported in part by NSF awards (DMR 1313553 and CMMI 1266116), NIH award (EB012575 and CA182670), and a research award from National Natural Sciences Foundation of China (31228007).

PY - 2014/1

Y1 - 2014/1

N2 - Biodegradable elastomers have recently found numerous applications in diverse areas of biomedical engineering, such as tissue engineering, drug delivery, gene delivery, and bioimaging. In particular, citrate-based biodegradable elastomeric polymers (CABEs) have gained significant attention in recent years. Along with being natural and biocompatible (a Krebs cycle product), citric acid is unique as its multifunctionality confers great freedom in designing a variety of biodegradable polymers with unique physical and chemical properties. This review will discuss the design strategies of CABE polymers and review their applications including cardiovascular, orthopedic, and nerve tissue engineering, bioimaging, tissue adhesives, drug/cell/gene delivery, and endoscopic mucosal resection. It is our hope that this book chapter will provide insightful discussion on previous CABE design, leading to the next innovation of citrate-based biomaterials and biomedical applications.

AB - Biodegradable elastomers have recently found numerous applications in diverse areas of biomedical engineering, such as tissue engineering, drug delivery, gene delivery, and bioimaging. In particular, citrate-based biodegradable elastomeric polymers (CABEs) have gained significant attention in recent years. Along with being natural and biocompatible (a Krebs cycle product), citric acid is unique as its multifunctionality confers great freedom in designing a variety of biodegradable polymers with unique physical and chemical properties. This review will discuss the design strategies of CABE polymers and review their applications including cardiovascular, orthopedic, and nerve tissue engineering, bioimaging, tissue adhesives, drug/cell/gene delivery, and endoscopic mucosal resection. It is our hope that this book chapter will provide insightful discussion on previous CABE design, leading to the next innovation of citrate-based biomaterials and biomedical applications.

UR - https://www.scopus.com/pages/publications/84902943046

UR - https://www.scopus.com/pages/publications/84902943046#tab=citedBy

U2 - 10.1016/B978-0-12-396983-5.00017-X

DO - 10.1016/B978-0-12-396983-5.00017-X

M3 - Chapter

AN - SCOPUS:84902943046

SN - 9780123969835

SP - 259

EP - 285

BT - Natural and Synthetic Biomedical Polymers

PB - Elsevier Inc.

ER -

Design Strategies and Applications of Citrate-Based Biodegradable Elastomeric Polymers

Abstract

All Science Journal Classification (ASJC) codes

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