Design, synthesis, and anti-breast cancer evaluation of new triarylethylene analogs bearing short alkyl- and polar amino-/amido-ethyl chains

Keyphrases

• Estrogen Receptor 100%
• Alkyl 100%
• MCF-7 100%
• Ethyl 100%
• Amino 100%
• Amido 100%
• Tetraarylethylene 100%
• Estrogen Receptor-negative 100%
• Ospemifene 100%
• Selective Estrogen Receptor Modulators 50%
• Binding Site 50%
• Binding Affinity 50%
• Metastasis 50%
• Dose Effect 50%
• MDA-MB-231 Cells 50%
• MDA-MB-231 Cancer Cells 50%
• Protein Expression 50%
• Human Breast Cancer Cell Lines 50%
• Matrix metalloproteinase-9 (MMP-9) 50%
• Estrogen Receptor-positive 50%
• C-Myc 50%
• Cytotoxic Activity 50%
• MCF-7 Cancer Cell Line 50%
• Anti-breast Cancer Agents 50%
• Caveolin 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Estrogen Receptor 100%
• Breast Cancer 100%
• Cancer Staging 100%
• Tamoxifen 40%
• Carcinogen 20%
• Malignant Neoplasm 20%
• Binding Site 20%
• Gelatinase B 20%
• Selective Estrogen Receptor Modulator 20%

Chemistry

• c-Myc 50%