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Design, synthesis, and biological evaluation of simplified α-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase

  • Thomas H. Marsilje
  • , Michael P. Hedrick
  • , Joel Desharnais
  • , Ali Tavassoli
  • , Yan Zhang
  • , Ian A. Wilson
  • , Stephen J. Benkovic
  • , Dale L. Boger

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Chemistry

Pharmacology, Toxicology and Pharmaceutical Science