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Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents
Saketh S. Dinavahi
, Raghavendra Gowda
,
Christopher G. Bazewicz
, Madhu Babu Battu
,
Jyh Ming Lin
, Robert J. Chitren
, Manoj K. Pandey
, Shantu Amin
,
Gavin P. Robertson
,
Krishne Gowda
Penn State Cancer Institute
Cancer Institute, Mechanisms of Carcinogenesis
Cancer Institute, Next-Generation Therapies
Department of Dermatology
Department of Molecular and Precision Medicine
Department of Pathology and Laboratory Medicine
Department of Surgery
Research output
:
Contribution to journal
›
Article
›
peer-review
39
Scopus citations
Overview
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Keyphrases
Novel Anticancer Agent
100%
Aldehyde Dehydrogenase 2 (ALDH2)
100%
Biological Evaluation
100%
Lipid Peroxidation
7%
In Cancer
7%
Apoptosis
7%
Melanoma Cells
7%
Toxicity Study
7%
Drug Resistance
7%
Poor Prognosis
7%
Colon Cancer Cells
7%
Stemness
7%
Cancer Stem Cells
7%
Enzymatic Assay
7%
Isatin
7%
Myeloma Cells
7%
Compound 3
7%
Detoxifying Enzymes
7%
Toxic Aldehydes
7%
Molecular Docking Studies
7%
Pharmacology, Toxicology and Pharmaceutical Science
Aldehyde Dehydrogenase
100%
Aldehyde Dehydrogenase Inhibitor
100%
Anticancer Drug
100%
Malignant Neoplasm
14%
Multiple Myeloma
14%
Melanoma
14%
Drug Resistance
14%
Colon Carcinoma
14%
Isatin
14%
Biochemistry, Genetics and Molecular Biology
ALDH1A1
18%
ALDH2
9%