Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle

Dipanjan Pan; Todd A. Williams; Angana Senpan; John S. Allen; Mike J. Scott; Patrick J. Gaffney; Samuel A. Wickline; Gregory M. Lanza

doi:10.1021/ja906797z

Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle

Dipanjan Pan, Todd A. Williams, Angana Senpan, John S. Allen, Mike J. Scott, Patrick J. Gaffney, Samuel A. Wickline, Gregory M. Lanza

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nanomolar particulate concentration range.

Original language	English (US)
Pages (from-to)	15522-15527
Number of pages	6
Journal	Journal of the American Chemical Society
Volume	131
Issue number	42
DOIs	https://doi.org/10.1021/ja906797z
State	Published - Oct 28 2009

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

Access to Document

10.1021/ja906797z

Cite this

@article{700b765550074634a78289a4829ae5e3,

title = "Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle",

abstract = "A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nanomolar particulate concentration range.",

author = "Dipanjan Pan and Williams, {Todd A.} and Angana Senpan and Allen, {John S.} and Scott, {Mike J.} and Gaffney, {Patrick J.} and Wickline, {Samuel A.} and Lanza, {Gregory M.}",

year = "2009",

month = oct,

day = "28",

doi = "10.1021/ja906797z",

language = "English (US)",

volume = "131",

pages = "15522--15527",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "42",

}

TY - JOUR

T1 - Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle

AU - Pan, Dipanjan

AU - Williams, Todd A.

AU - Senpan, Angana

AU - Allen, John S.

AU - Scott, Mike J.

AU - Gaffney, Patrick J.

AU - Wickline, Samuel A.

AU - Lanza, Gregory M.

PY - 2009/10/28

Y1 - 2009/10/28

N2 - A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nanomolar particulate concentration range.

AB - A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nanomolar particulate concentration range.

UR - http://www.scopus.com/inward/record.url?scp=70350332463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350332463&partnerID=8YFLogxK

U2 - 10.1021/ja906797z

DO - 10.1021/ja906797z

M3 - Article

C2 - 19795893

AN - SCOPUS:70350332463

SN - 0002-7863

VL - 131

SP - 15522

EP - 15527

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 42

ER -

Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this