Detection and characterization of 1,2-dibromoethane-derived dna crosslinks formed with O6-alkylguanine-DNA alkyltransferase

Goutam Chowdhury; Sung Hee Cho; Anthony Pegg; F. Peter Guengerich

doi:10.1002/anie.201307580

Detection and characterization of 1,2-dibromoethane-derived dna crosslinks formed with O⁶-alkylguanine-DNA alkyltransferase

Goutam Chowdhury, Sung Hee Cho, Anthony Pegg, F. Peter Guengerich

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A combination of chemical modifications and LC-tandem MS was used for the structure elucidation of various ethylene crosslinks of DNA with O ⁶-alkylguanine-DNA alkyltransferase (AGT, see picture). The elucidation of the chemical structures of such DNA-protein crosslinks is necessary to understand mechanisms of mutagenesis.

Original language	English (US)
Pages (from-to)	12879-12882
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	49
DOIs	https://doi.org/10.1002/anie.201307580
State	Published - Dec 2 2013

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry

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abstract = "A combination of chemical modifications and LC-tandem MS was used for the structure elucidation of various ethylene crosslinks of DNA with O 6-alkylguanine-DNA alkyltransferase (AGT, see picture). The elucidation of the chemical structures of such DNA-protein crosslinks is necessary to understand mechanisms of mutagenesis.",

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AU - Guengerich, F. Peter

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Detection and characterization of 1,2-dibromoethane-derived dna crosslinks formed with O⁶-alkylguanine-DNA alkyltransferase

Abstract

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