Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam

Dung Van Nguyen; Cuong Van Nguyen; David Bonsall; Tue Tri Ngo; Juan Carrique-Mas; Anh Hong Pham; Juliet E. Bryant; Guy Thwaites; Stephen Baker; Mark Woolhouse; Peter Simmonds; Bach Tuan Kiet; Alessandra Berto; Maciej F. Boni; Juliet E. Bryant; Bui Duc Phu; James I. Campbell; Dang Manh Hung; Dang Thao Huong; Dang Tram Oanh; Jeremy N. Day; Dinh Van Tan; H. Rogier van Doorn; Duong An Han; Jeremy J. Farrar; Hau Thi Thu Trang; Ho Dang Trung Nghia; Hoang Bao Long; Hoang Van Duong; Huynh Thi Kim Thu; Lam Chi Cuong; Le Manh Hung; Le Thanh Phuong; Le Thi Phuc; Le Thi Phuong; Le Xuan Luat; Luu Thi Thu Ha; Ly Van Chuong; Mai Thi Phuoc Loan; Behzad Nadjm; Ngo Thanh Bao; Ngo Thi Hoa; Ngo Tri Tue; Nguyen Canh Tu; Nguyen Dac Thuan; Nguyen Dong; Nguyen Khac Chuyen; Nguyen Ngoc An; Nguyen Ngoc Vinh; Nguyen Quoc Hung; Nguyen Thanh Dung; Nguyen Thanh Minh; Nguyen Thi Binh; Nguyen Thi Hong Tham; Nguyen Thi Hong Tien; Nguyen Thi Kim Chuc; Nguyen Thi Le Ngoc; Nguyen Thi Lien Ha; Nguyen Thi Nam Lien; Nguyen Thi Ngoc Diep; Nguyen Thi Nhung; Nguyen Thi Song Chau; Nguyen Thi Yen Chi; Nguyen Thieu Trinh; Nguyen Thu Van; Nguyen Van Cuong; Nguyen Van Hung; Nguyen Van Kinh; Nguyen Van Minh Hoang; Nguyen Van My; Nguyen Van Thang; Nguyen Van Thanh; Nguyen Van Vinh Chau; Nguyen Van Xang; Pham Ha My; Pham Hong Anh; Pham Thi Minh Khoa; Pham Thi Thanh Tam; Pham Van Lao; Pham Van Minh; Phan Van Be Bay; Maia A. Rabaa; Motiur Rahman; Corinne Thompson; Ta Thi Dieu Ngan; Tran Do Hoang Nhu; Tran Hoang Minh Chau; Tran Khanh Toan; Tran My Phuc; Tran Thi Kim Hong; Tran Thi Ngoc Dung; Tran Thi Thanh Thanh; Tran Thi Thuy Minh; Tran Thua Nguyen; Tran Tinh Hien; Trinh Quang Tri; Vo Be Hien; Vo Nhut Tai; Vo Quoc Cuong; Voong Vinh Phat; Vu Thi Lan Huong; Vu Thi Ty Hang; Heiman Wertheim; Carlijn Bogaardt; Liam Brierley; Margo Chase-Topping; Al Ivens; Lu Lu; Dung Nguyen; Andrew Rambaut; Matthew Cotten; Bas B.Oude Munnink; Paul Kellam; My Vu Tra Phan; Lia van der Hoek; Martin Deijs; Maarten F. Jebbink; Seyed Mohammad Jazaeri Farsani; Karen Saylors; Nathan Wolfe

doi:10.3390/v10030102

Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam

Dung Van Nguyen, Cuong Van Nguyen, David Bonsall, Tue Tri Ngo, Juan Carrique-Mas, Anh Hong Pham, Juliet E. Bryant, Guy Thwaites, Stephen Baker, Mark Woolhouse, Peter Simmonds, Bach Tuan Kiet, Alessandra Berto, Maciej F. Boni, Juliet E. Bryant, Bui Duc Phu, James I. Campbell, Dang Manh Hung, Dang Thao Huong, Dang Tram OanhJeremy N. Day, Dinh Van Tan, H. Rogier van Doorn, Duong An Han, Jeremy J. Farrar, Hau Thi Thu Trang, Ho Dang Trung Nghia, Hoang Bao Long, Hoang Van Duong, Huynh Thi Kim Thu, Lam Chi Cuong, Le Manh Hung, Le Thanh Phuong, Le Thi Phuc, Le Thi Phuong, Le Xuan Luat, Luu Thi Thu Ha, Ly Van Chuong, Mai Thi Phuoc Loan, Behzad Nadjm, Ngo Thanh Bao, Ngo Thi Hoa, Ngo Tri Tue, Nguyen Canh Tu, Nguyen Dac Thuan, Nguyen Dong, Nguyen Khac Chuyen, Nguyen Ngoc An, Nguyen Ngoc Vinh, Nguyen Quoc Hung, Nguyen Thanh Dung, Nguyen Thanh Minh, Nguyen Thi Binh, Nguyen Thi Hong Tham, Nguyen Thi Hong Tien, Nguyen Thi Kim Chuc, Nguyen Thi Le Ngoc, Nguyen Thi Lien Ha, Nguyen Thi Nam Lien, Nguyen Thi Ngoc Diep, Nguyen Thi Nhung, Nguyen Thi Song Chau, Nguyen Thi Yen Chi, Nguyen Thieu Trinh, Nguyen Thu Van, Nguyen Van Cuong, Nguyen Van Hung, Nguyen Van Kinh, Nguyen Van Minh Hoang, Nguyen Van My, Nguyen Van Thang, Nguyen Van Thanh, Nguyen Van Vinh Chau, Nguyen Van Xang, Pham Ha My, Pham Hong Anh, Pham Thi Minh Khoa, Pham Thi Thanh Tam, Pham Van Lao, Pham Van Minh, Phan Van Be Bay, Maia A. Rabaa, Motiur Rahman, Corinne Thompson, Ta Thi Dieu Ngan, Tran Do Hoang Nhu, Tran Hoang Minh Chau, Tran Khanh Toan, Tran My Phuc, Tran Thi Kim Hong, Tran Thi Ngoc Dung, Tran Thi Thanh Thanh, Tran Thi Thuy Minh, Tran Thua Nguyen, Tran Tinh Hien, Trinh Quang Tri, Vo Be Hien, Vo Nhut Tai, Vo Quoc Cuong, Voong Vinh Phat, Vu Thi Lan Huong, Vu Thi Ty Hang, Heiman Wertheim, Carlijn Bogaardt, Liam Brierley, Margo Chase-Topping, Al Ivens, Lu Lu, Dung Nguyen, Andrew Rambaut, Matthew Cotten, Bas B.Oude Munnink, Paul Kellam, My Vu Tra Phan, Lia van der Hoek, Martin Deijs, Maarten F. Jebbink, Seyed Mohammad Jazaeri Farsani, Karen Saylors, Nathan Wolfe

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, Rhizomys pruinosus, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the Hepacivirus genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined.

Original language	English (US)
Article number	102
Journal	Viruses
Volume	10
Issue number	3
DOIs	https://doi.org/10.3390/v10030102
State	Published - Mar 1 2018

All Science Journal Classification (ASJC) codes

Infectious Diseases
Virology

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10.3390/v10030102

Cite this

Van Nguyen, D., Van Nguyen, C., Bonsall, D., Ngo, T. T., Carrique-Mas, J., Pham, A. H., Bryant, J. E., Thwaites, G., Baker, S., Woolhouse, M., Simmonds, P., Kiet, B. T., Berto, A., Boni, M. F., Bryant, J. E., Phu, B. D., Campbell, J. I., Hung, D. M., Huong, D. T., ... Wolfe, N. (2018). Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam. Viruses, 10(3), Article 102. https://doi.org/10.3390/v10030102

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title = "Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam",

abstract = "Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, Rhizomys pruinosus, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the Hepacivirus genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined.",

author = "{Van Nguyen}, Dung and {Van Nguyen}, Cuong and David Bonsall and Ngo, {Tue Tri} and Juan Carrique-Mas and Pham, {Anh Hong} and Bryant, {Juliet E.} and Guy Thwaites and Stephen Baker and Mark Woolhouse and Peter Simmonds and Kiet, {Bach Tuan} and Alessandra Berto and Boni, {Maciej F.} and Bryant, {Juliet E.} and Phu, {Bui Duc} and Campbell, {James I.} and Hung, {Dang Manh} and Huong, {Dang Thao} and Oanh, {Dang Tram} and Day, {Jeremy N.} and Tan, {Dinh Van} and {van Doorn}, {H. Rogier} and Han, {Duong An} and Farrar, {Jeremy J.} and Trang, {Hau Thi Thu} and Nghia, {Ho Dang Trung} and Long, {Hoang Bao} and Duong, {Hoang Van} and Thu, {Huynh Thi Kim} and Cuong, {Lam Chi} and Hung, {Le Manh} and Phuong, {Le Thanh} and Phuc, {Le Thi} and Phuong, {Le Thi} and Luat, {Le Xuan} and Ha, {Luu Thi Thu} and Chuong, {Ly Van} and Loan, {Mai Thi Phuoc} and Behzad Nadjm and Bao, {Ngo Thanh} and Hoa, {Ngo Thi} and Tue, {Ngo Tri} and Tu, {Nguyen Canh} and Thuan, {Nguyen Dac} and Nguyen Dong and Chuyen, {Nguyen Khac} and An, {Nguyen Ngoc} and Vinh, {Nguyen Ngoc} and Hung, {Nguyen Quoc} and Dung, {Nguyen Thanh} and Minh, {Nguyen Thanh} and Binh, {Nguyen Thi} and Tham, {Nguyen Thi Hong} and Tien, {Nguyen Thi Hong} and Chuc, {Nguyen Thi Kim} and Ngoc, {Nguyen Thi Le} and Ha, {Nguyen Thi Lien} and Lien, {Nguyen Thi Nam} and Diep, {Nguyen Thi Ngoc} and Nhung, {Nguyen Thi} and Chau, {Nguyen Thi Song} and Chi, {Nguyen Thi Yen} and Trinh, {Nguyen Thieu} and Van, {Nguyen Thu} and Cuong, {Nguyen Van} and Hung, {Nguyen Van} and Kinh, {Nguyen Van} and Hoang, {Nguyen Van Minh} and My, {Nguyen Van} and Thang, {Nguyen Van} and Thanh, {Nguyen Van} and Chau, {Nguyen Van Vinh} and Xang, {Nguyen Van} and My, {Pham Ha} and Anh, {Pham Hong} and Khoa, {Pham Thi Minh} and Tam, {Pham Thi Thanh} and Lao, {Pham Van} and Minh, {Pham Van} and Bay, {Phan Van Be} and Rabaa, {Maia A.} and Motiur Rahman and Corinne Thompson and Ngan, {Ta Thi Dieu} and Nhu, {Tran Do Hoang} and Chau, {Tran Hoang Minh} and Toan, {Tran Khanh} and Phuc, {Tran My} and Hong, {Tran Thi Kim} and Dung, {Tran Thi Ngoc} and Thanh, {Tran Thi Thanh} and Minh, {Tran Thi Thuy} and Nguyen, {Tran Thua} and Hien, {Tran Tinh} and Tri, {Trinh Quang} and Hien, {Vo Be} and Tai, {Vo Nhut} and Cuong, {Vo Quoc} and Phat, {Voong Vinh} and Huong, {Vu Thi Lan} and Hang, {Vu Thi Ty} and Heiman Wertheim and Carlijn Bogaardt and Liam Brierley and Margo Chase-Topping and Al Ivens and Lu Lu and Dung Nguyen and Andrew Rambaut and Matthew Cotten and Munnink, {Bas B.Oude} and Paul Kellam and Phan, {My Vu Tra} and {van der Hoek}, Lia and Martin Deijs and Jebbink, {Maarten F.} and Farsani, {Seyed Mohammad Jazaeri} and Karen Saylors and Nathan Wolfe",

note = "Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2018",

month = mar,

day = "1",

doi = "10.3390/v10030102",

language = "English (US)",

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Van Nguyen, D, Van Nguyen, C, Bonsall, D, Ngo, TT, Carrique-Mas, J, Pham, AH, Bryant, JE, Thwaites, G, Baker, S, Woolhouse, M, Simmonds, P, Kiet, BT, Berto, A, Boni, MF, Bryant, JE, Phu, BD, Campbell, JI, Hung, DM, Huong, DT, Oanh, DT, Day, JN, Tan, DV, van Doorn, HR, Han, DA, Farrar, JJ, Trang, HTT, Nghia, HDT, Long, HB, Duong, HV, Thu, HTK, Cuong, LC, Hung, LM, Phuong, LT, Phuc, LT, Phuong, LT, Luat, LX, Ha, LTT, Chuong, LV, Loan, MTP, Nadjm, B, Bao, NT, Hoa, NT, Tue, NT, Tu, NC, Thuan, ND, Dong, N, Chuyen, NK, An, NN, Vinh, NN, Hung, NQ, Dung, NT, Minh, NT, Binh, NT, Tham, NTH, Tien, NTH, Chuc, NTK, Ngoc, NTL, Ha, NTL, Lien, NTN, Diep, NTN, Nhung, NT, Chau, NTS, Chi, NTY, Trinh, NT, Van, NT, Cuong, NV, Hung, NV, Kinh, NV, Hoang, NVM, My, NV, Thang, NV, Thanh, NV, Chau, NVV, Xang, NV, My, PH, Anh, PH, Khoa, PTM, Tam, PTT, Lao, PV, Minh, PV, Bay, PVB, Rabaa, MA, Rahman, M, Thompson, C, Ngan, TTD, Nhu, TDH, Chau, THM, Toan, TK, Phuc, TM, Hong, TTK, Dung, TTN, Thanh, TTT, Minh, TTT, Nguyen, TT, Hien, TT, Tri, TQ, Hien, VB, Tai, VN, Cuong, VQ, Phat, VV, Huong, VTL, Hang, VTT, Wertheim, H, Bogaardt, C, Brierley, L, Chase-Topping, M, Ivens, A, Lu, L, Nguyen, D, Rambaut, A, Cotten, M, Munnink, BBO, Kellam, P, Phan, MVT, van der Hoek, L, Deijs, M, Jebbink, MF, Farsani, SMJ, Saylors, K & Wolfe, N 2018, 'Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam', Viruses, vol. 10, no. 3, 102. https://doi.org/10.3390/v10030102

TY - JOUR

T1 - Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam

AU - Van Nguyen, Dung

AU - Van Nguyen, Cuong

AU - Bonsall, David

AU - Ngo, Tue Tri

AU - Carrique-Mas, Juan

AU - Pham, Anh Hong

AU - Bryant, Juliet E.

AU - Thwaites, Guy

AU - Baker, Stephen

AU - Woolhouse, Mark

AU - Simmonds, Peter

AU - Kiet, Bach Tuan

AU - Berto, Alessandra

AU - Boni, Maciej F.

AU - Bryant, Juliet E.

AU - Phu, Bui Duc

AU - Campbell, James I.

AU - Hung, Dang Manh

AU - Huong, Dang Thao

AU - Oanh, Dang Tram

AU - Day, Jeremy N.

AU - Tan, Dinh Van

AU - van Doorn, H. Rogier

AU - Han, Duong An

AU - Farrar, Jeremy J.

AU - Trang, Hau Thi Thu

AU - Nghia, Ho Dang Trung

AU - Long, Hoang Bao

AU - Duong, Hoang Van

AU - Thu, Huynh Thi Kim

AU - Cuong, Lam Chi

AU - Hung, Le Manh

AU - Phuong, Le Thanh

AU - Phuc, Le Thi

AU - Phuong, Le Thi

AU - Luat, Le Xuan

AU - Ha, Luu Thi Thu

AU - Chuong, Ly Van

AU - Loan, Mai Thi Phuoc

AU - Nadjm, Behzad

AU - Bao, Ngo Thanh

AU - Hoa, Ngo Thi

AU - Tue, Ngo Tri

AU - Tu, Nguyen Canh

AU - Thuan, Nguyen Dac

AU - Dong, Nguyen

AU - Chuyen, Nguyen Khac

AU - An, Nguyen Ngoc

AU - Vinh, Nguyen Ngoc

AU - Hung, Nguyen Quoc

AU - Dung, Nguyen Thanh

AU - Minh, Nguyen Thanh

AU - Binh, Nguyen Thi

AU - Tham, Nguyen Thi Hong

AU - Tien, Nguyen Thi Hong

AU - Chuc, Nguyen Thi Kim

AU - Ngoc, Nguyen Thi Le

AU - Ha, Nguyen Thi Lien

AU - Lien, Nguyen Thi Nam

AU - Diep, Nguyen Thi Ngoc

AU - Nhung, Nguyen Thi

AU - Chau, Nguyen Thi Song

AU - Chi, Nguyen Thi Yen

AU - Trinh, Nguyen Thieu

AU - Van, Nguyen Thu

AU - Cuong, Nguyen Van

AU - Hung, Nguyen Van

AU - Kinh, Nguyen Van

AU - Hoang, Nguyen Van Minh

AU - My, Nguyen Van

AU - Thang, Nguyen Van

AU - Thanh, Nguyen Van

AU - Chau, Nguyen Van Vinh

AU - Xang, Nguyen Van

AU - My, Pham Ha

AU - Anh, Pham Hong

AU - Khoa, Pham Thi Minh

AU - Tam, Pham Thi Thanh

AU - Lao, Pham Van

AU - Minh, Pham Van

AU - Bay, Phan Van Be

AU - Rabaa, Maia A.

AU - Rahman, Motiur

AU - Thompson, Corinne

AU - Ngan, Ta Thi Dieu

AU - Nhu, Tran Do Hoang

AU - Chau, Tran Hoang Minh

AU - Toan, Tran Khanh

AU - Phuc, Tran My

AU - Hong, Tran Thi Kim

AU - Dung, Tran Thi Ngoc

AU - Thanh, Tran Thi Thanh

AU - Minh, Tran Thi Thuy

AU - Nguyen, Tran Thua

AU - Hien, Tran Tinh

AU - Tri, Trinh Quang

AU - Hien, Vo Be

AU - Tai, Vo Nhut

AU - Cuong, Vo Quoc

AU - Phat, Voong Vinh

AU - Huong, Vu Thi Lan

AU - Hang, Vu Thi Ty

AU - Wertheim, Heiman

AU - Bogaardt, Carlijn

AU - Brierley, Liam

AU - Chase-Topping, Margo

AU - Ivens, Al

AU - Lu, Lu

AU - Nguyen, Dung

AU - Rambaut, Andrew

AU - Cotten, Matthew

AU - Munnink, Bas B.Oude

AU - Kellam, Paul

AU - Phan, My Vu Tra

AU - van der Hoek, Lia

AU - Deijs, Martin

AU - Jebbink, Maarten F.

AU - Farsani, Seyed Mohammad Jazaeri

AU - Saylors, Karen

AU - Wolfe, Nathan

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, Rhizomys pruinosus, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the Hepacivirus genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined.

AB - Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, Rhizomys pruinosus, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the Hepacivirus genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined.

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U2 - 10.3390/v10030102

DO - 10.3390/v10030102

M3 - Article

C2 - 29495551

AN - SCOPUS:85042781508

SN - 1999-4915

VL - 10

JO - Viruses

JF - Viruses

IS - 3

M1 - 102

ER -

Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam

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