Detection of benign granular cell tumor of the breast via 18F-PSMA-PET/CT in a patient with very high-risk prostate cancer: A case report

Kamyar Ghabili; Rushi Rajyaguru; Alexandra De La Plante; Kristine L. Widders; Alison L. Chetlen; Angela I. Choe; Claudia J. Kasales

doi:10.1177/2050313X241275826

Detection of benign granular cell tumor of the breast via ¹⁸F-PSMA-PET/CT in a patient with very high-risk prostate cancer: A case report

Kamyar Ghabili, Rushi Rajyaguru, Alexandra De La Plante, Kristine L. Widders, Alison L. Chetlen, Angela I. Choe, Claudia J. Kasales

Research output: Contribution to journal › Article › peer-review

Abstract

Incidental extra-prostatic prostate-specific membrane antigen (PSMA) uptake on initial staging positron emission tomography/computed tomography (PET/CT) scans poses diagnostic challenges, as it can be associated with various benign and malignant lesions. We present the case of a 68-year-old man with very high-risk prostate cancer who was incidentally discovered to have a benign granular cell tumor in the breast initially detected on PSMA-PET/CT. Imaging studies and biopsy were pivotal in the diagnosis, as the tumor’s appearance was concerning for breast carcinoma. Recognizing extra-prostatic PSMA uptake in the breast, particularly in patients with prostate cancer, is crucial for guiding appropriate management, accurately interpreting subsequent imaging findings, and assessing radiologic-pathologic correlation.

Original language	English (US)
Journal	SAGE Open Medical Case Reports
Volume	12
DOIs	https://doi.org/10.1177/2050313X241275826
State	Published - Jan 1 2024

All Science Journal Classification (ASJC) codes

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/2050313X241275826

Cite this

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title = "Detection of benign granular cell tumor of the breast via 18F-PSMA-PET/CT in a patient with very high-risk prostate cancer: A case report",

abstract = "Incidental extra-prostatic prostate-specific membrane antigen (PSMA) uptake on initial staging positron emission tomography/computed tomography (PET/CT) scans poses diagnostic challenges, as it can be associated with various benign and malignant lesions. We present the case of a 68-year-old man with very high-risk prostate cancer who was incidentally discovered to have a benign granular cell tumor in the breast initially detected on PSMA-PET/CT. Imaging studies and biopsy were pivotal in the diagnosis, as the tumor{\textquoteright}s appearance was concerning for breast carcinoma. Recognizing extra-prostatic PSMA uptake in the breast, particularly in patients with prostate cancer, is crucial for guiding appropriate management, accurately interpreting subsequent imaging findings, and assessing radiologic-pathologic correlation.",

author = "Kamyar Ghabili and Rushi Rajyaguru and {De La Plante}, Alexandra and Widders, {Kristine L.} and Chetlen, {Alison L.} and Choe, {Angela I.} and Kasales, {Claudia J.}",

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AU - Ghabili, Kamyar

AU - Rajyaguru, Rushi

AU - De La Plante, Alexandra

AU - Widders, Kristine L.

AU - Chetlen, Alison L.

AU - Choe, Angela I.

AU - Kasales, Claudia J.

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AB - Incidental extra-prostatic prostate-specific membrane antigen (PSMA) uptake on initial staging positron emission tomography/computed tomography (PET/CT) scans poses diagnostic challenges, as it can be associated with various benign and malignant lesions. We present the case of a 68-year-old man with very high-risk prostate cancer who was incidentally discovered to have a benign granular cell tumor in the breast initially detected on PSMA-PET/CT. Imaging studies and biopsy were pivotal in the diagnosis, as the tumor’s appearance was concerning for breast carcinoma. Recognizing extra-prostatic PSMA uptake in the breast, particularly in patients with prostate cancer, is crucial for guiding appropriate management, accurately interpreting subsequent imaging findings, and assessing radiologic-pathologic correlation.

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