Detection of Leukemia-Related Karyotypes in Granulocyte/Macrophage Colonies from a Patient with Acute Myelomonocytic Leukemia

Michael M. Reid; Ramana Tantravahi; Holcombe E. Grier; Susan O'toole; Barbara A. Miller; Jeffrey M. Lipton; Howard J. Weinstein; David G. Nathan

doi:10.1056/NEJM198306023082204

Detection of Leukemia-Related Karyotypes in Granulocyte/Macrophage Colonies from a Patient with Acute Myelomonocytic Leukemia

Michael M. Reid, Ramana Tantravahi, Holcombe E. Grier, Susan O'toole, Barbara A. Miller, Jeffrey M. Lipton, Howard J. Weinstein, David G. Nathan

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The use of chromosome-banding techniques to identify metaphase chromosomes in hematopoietic colonies derived from marrow cultures from patients with acute nonlymphocytic leukemia (ANLL) offers an opportunity to study the extent of involvement of progenitor cells in the leukemic process. Several lines of evidence have demonstrated that chronic myelogenous leukemia is a clonal hematopoietic stem-cell disorder.¹ The Philadelphia chromosome, detectable in 90 per cent of patients with chronic myelogenous leukemia, has been found in colonies grown from committed granulocyte and erythroid progenitors in vitro.^2,3 Other studies have used female patients who were heterozygous for the X-chromosome-linked enzyme glucose-6-phosphate dehydrogenase. Both forms.

Original language	English (US)
Pages (from-to)	1324-1328
Number of pages	5
Journal	New England Journal of Medicine
Volume	308
Issue number	22
DOIs	https://doi.org/10.1056/NEJM198306023082204
State	Published - Jun 2 1983

All Science Journal Classification (ASJC) codes

General Medicine

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10.1056/NEJM198306023082204

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title = "Detection of Leukemia-Related Karyotypes in Granulocyte/Macrophage Colonies from a Patient with Acute Myelomonocytic Leukemia",

abstract = "The use of chromosome-banding techniques to identify metaphase chromosomes in hematopoietic colonies derived from marrow cultures from patients with acute nonlymphocytic leukemia (ANLL) offers an opportunity to study the extent of involvement of progenitor cells in the leukemic process. Several lines of evidence have demonstrated that chronic myelogenous leukemia is a clonal hematopoietic stem-cell disorder.1 The Philadelphia chromosome, detectable in 90 per cent of patients with chronic myelogenous leukemia, has been found in colonies grown from committed granulocyte and erythroid progenitors in vitro.2,3 Other studies have used female patients who were heterozygous for the X-chromosome-linked enzyme glucose-6-phosphate dehydrogenase. Both forms.",

author = "Reid, {Michael M.} and Ramana Tantravahi and Grier, {Holcombe E.} and Susan O'toole and Miller, {Barbara A.} and Lipton, {Jeffrey M.} and Weinstein, {Howard J.} and Nathan, {David G.}",

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AU - Reid, Michael M.

AU - Tantravahi, Ramana

AU - Grier, Holcombe E.

AU - O'toole, Susan

AU - Miller, Barbara A.

AU - Lipton, Jeffrey M.

AU - Weinstein, Howard J.

AU - Nathan, David G.

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Y1 - 1983/6/2

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AB - The use of chromosome-banding techniques to identify metaphase chromosomes in hematopoietic colonies derived from marrow cultures from patients with acute nonlymphocytic leukemia (ANLL) offers an opportunity to study the extent of involvement of progenitor cells in the leukemic process. Several lines of evidence have demonstrated that chronic myelogenous leukemia is a clonal hematopoietic stem-cell disorder.1 The Philadelphia chromosome, detectable in 90 per cent of patients with chronic myelogenous leukemia, has been found in colonies grown from committed granulocyte and erythroid progenitors in vitro.2,3 Other studies have used female patients who were heterozygous for the X-chromosome-linked enzyme glucose-6-phosphate dehydrogenase. Both forms.

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Detection of Leukemia-Related Karyotypes in Granulocyte/Macrophage Colonies from a Patient with Acute Myelomonocytic Leukemia

Abstract

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