TY - JOUR
T1 - Determinants of ligand affinity and heme reactivity in H-NOX domains
AU - Weinert, Emily E.
AU - Plate, Lars
AU - Whited, Charlotte A.
AU - Olea, Charles
AU - Marletta, Michael A.
PY - 2010/1/18
Y1 - 2010/1/18
N2 - Figure Presented O2 balks at extra bulk: The introduction of distal-pocket bulk into the Thermoanaerobacter tengcongensis H-NOX (heme nitric oxide/oxygen) domain caused key changes in the protein structure. Rearrangement of the heme pocket resulted in dramatic differences in O2-binding kinetics and heme reactivity (see picture).
AB - Figure Presented O2 balks at extra bulk: The introduction of distal-pocket bulk into the Thermoanaerobacter tengcongensis H-NOX (heme nitric oxide/oxygen) domain caused key changes in the protein structure. Rearrangement of the heme pocket resulted in dramatic differences in O2-binding kinetics and heme reactivity (see picture).
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U2 - 10.1002/anie.200904799
DO - 10.1002/anie.200904799
M3 - Article
C2 - 20017169
AN - SCOPUS:74849124388
SN - 1433-7851
VL - 49
SP - 720
EP - 723
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 4
ER -