Determinants of ligand affinity and heme reactivity in H-NOX domains

Emily E. Weinert; Lars Plate; Charlotte A. Whited; Charles Olea; Michael A. Marletta

doi:10.1002/anie.200904799

Determinants of ligand affinity and heme reactivity in H-NOX domains

Emily E. Weinert
, Lars Plate
, Charlotte A. Whited
, Charles Olea
, Michael A. Marletta

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Figure Presented O₂ balks at extra bulk: The introduction of distal-pocket bulk into the Thermoanaerobacter tengcongensis H-NOX (heme nitric oxide/oxygen) domain caused key changes in the protein structure. Rearrangement of the heme pocket resulted in dramatic differences in O₂-binding kinetics and heme reactivity (see picture).

Original language	English (US)
Pages (from-to)	720-723
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	4
DOIs	https://doi.org/10.1002/anie.200904799
State	Published - Jan 18 2010

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry

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10.1002/anie.200904799

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title = "Determinants of ligand affinity and heme reactivity in H-NOX domains",

abstract = "Figure Presented O2 balks at extra bulk: The introduction of distal-pocket bulk into the Thermoanaerobacter tengcongensis H-NOX (heme nitric oxide/oxygen) domain caused key changes in the protein structure. Rearrangement of the heme pocket resulted in dramatic differences in O2-binding kinetics and heme reactivity (see picture).",

author = "Weinert, \{Emily E.\} and Lars Plate and Whited, \{Charlotte A.\} and Charles Olea and Marletta, \{Michael A.\}",

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T1 - Determinants of ligand affinity and heme reactivity in H-NOX domains

AU - Weinert, Emily E.

AU - Plate, Lars

AU - Whited, Charlotte A.

AU - Olea, Charles

AU - Marletta, Michael A.

PY - 2010/1/18

Y1 - 2010/1/18

N2 - Figure Presented O2 balks at extra bulk: The introduction of distal-pocket bulk into the Thermoanaerobacter tengcongensis H-NOX (heme nitric oxide/oxygen) domain caused key changes in the protein structure. Rearrangement of the heme pocket resulted in dramatic differences in O2-binding kinetics and heme reactivity (see picture).

AB - Figure Presented O2 balks at extra bulk: The introduction of distal-pocket bulk into the Thermoanaerobacter tengcongensis H-NOX (heme nitric oxide/oxygen) domain caused key changes in the protein structure. Rearrangement of the heme pocket resulted in dramatic differences in O2-binding kinetics and heme reactivity (see picture).

UR - https://www.scopus.com/pages/publications/74849124388

UR - https://www.scopus.com/pages/publications/74849124388#tab=citedBy

U2 - 10.1002/anie.200904799

DO - 10.1002/anie.200904799

M3 - Article

C2 - 20017169

AN - SCOPUS:74849124388

SN - 1433-7851

VL - 49

SP - 720

EP - 723

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 4

ER -

Determinants of ligand affinity and heme reactivity in H-NOX domains

Abstract

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