Determinants of normal and increased microvessel permeability

Fitz Roy E Curry; Roger H. Adamson; Bing Mei Fu; Ping He; Joyce F. Lenz; Mayumi Kajimura; Stamatis N. Pagakis; Sheldon Weinbaum

Determinants of normal and increased microvessel permeability

Fitz Roy E Curry, Roger H. Adamson, Bing Mei Fu, Ping He, Joyce F. Lenz, Mayumi Kajimura, Stamatis N. Pagakis, Sheldon Weinbaum

Department of Cellular and Molecular Physiology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The molecular structures which determine the normal permeability properties of the capillary wall and modulate changes in microvessel permeability include the cell surface glycocalyx, the junctional strands in the cleft between the adjacent endothelial cells, and the endothelial cell attachment sites to the extracellular matrix. To evaluate the role of the glycocalyx and junctional strand geometry as determinants of normal permeability properties, a 3D model was developed for water and solute flow through the cleft between the adjacent cells. To identify the very small pore pathway, a time-dependent diffusion model was developed for analysis of concentration profiles of electron dense small tracers in the interendothelial clefts.

Original language	English (US)
Title of host publication	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Publisher	ASME
Pages	71-72
Number of pages	2
Volume	29
State	Published - 1995
Event	Proceedings of the 1995 Bioengineering Conference - Beever Creek, CO, USA Duration: Jun 28 1995 → Jul 2 1995

Other

Other	Proceedings of the 1995 Bioengineering Conference
City	Beever Creek, CO, USA
Period	6/28/95 → 7/2/95

All Science Journal Classification (ASJC) codes

General Engineering

Cite this

@inproceedings{5bbbfd73d7794fb888a056067adcba74,

title = "Determinants of normal and increased microvessel permeability",

abstract = "The molecular structures which determine the normal permeability properties of the capillary wall and modulate changes in microvessel permeability include the cell surface glycocalyx, the junctional strands in the cleft between the adjacent endothelial cells, and the endothelial cell attachment sites to the extracellular matrix. To evaluate the role of the glycocalyx and junctional strand geometry as determinants of normal permeability properties, a 3D model was developed for water and solute flow through the cleft between the adjacent cells. To identify the very small pore pathway, a time-dependent diffusion model was developed for analysis of concentration profiles of electron dense small tracers in the interendothelial clefts.",

author = "Curry, {Fitz Roy E} and Adamson, {Roger H.} and Fu, {Bing Mei} and Ping He and Lenz, {Joyce F.} and Mayumi Kajimura and Pagakis, {Stamatis N.} and Sheldon Weinbaum",

year = "1995",

language = "English (US)",

volume = "29",

pages = "71--72",

booktitle = "American Society of Mechanical Engineers, Bioengineering Division (Publication) BED",

publisher = "ASME",

note = "Proceedings of the 1995 Bioengineering Conference ; Conference date: 28-06-1995 Through 02-07-1995",

}

TY - GEN

T1 - Determinants of normal and increased microvessel permeability

AU - Curry, Fitz Roy E

AU - Adamson, Roger H.

AU - Fu, Bing Mei

AU - He, Ping

AU - Lenz, Joyce F.

AU - Kajimura, Mayumi

AU - Pagakis, Stamatis N.

AU - Weinbaum, Sheldon

PY - 1995

Y1 - 1995

N2 - The molecular structures which determine the normal permeability properties of the capillary wall and modulate changes in microvessel permeability include the cell surface glycocalyx, the junctional strands in the cleft between the adjacent endothelial cells, and the endothelial cell attachment sites to the extracellular matrix. To evaluate the role of the glycocalyx and junctional strand geometry as determinants of normal permeability properties, a 3D model was developed for water and solute flow through the cleft between the adjacent cells. To identify the very small pore pathway, a time-dependent diffusion model was developed for analysis of concentration profiles of electron dense small tracers in the interendothelial clefts.

AB - The molecular structures which determine the normal permeability properties of the capillary wall and modulate changes in microvessel permeability include the cell surface glycocalyx, the junctional strands in the cleft between the adjacent endothelial cells, and the endothelial cell attachment sites to the extracellular matrix. To evaluate the role of the glycocalyx and junctional strand geometry as determinants of normal permeability properties, a 3D model was developed for water and solute flow through the cleft between the adjacent cells. To identify the very small pore pathway, a time-dependent diffusion model was developed for analysis of concentration profiles of electron dense small tracers in the interendothelial clefts.

UR - http://www.scopus.com/inward/record.url?scp=0029227072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029227072&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0029227072

VL - 29

SP - 71

EP - 72

BT - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

PB - ASME

T2 - Proceedings of the 1995 Bioengineering Conference

Y2 - 28 June 1995 through 2 July 1995

ER -

Determinants of normal and increased microvessel permeability

Abstract

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All Science Journal Classification (ASJC) codes

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