TY - JOUR
T1 - Determinants of plasma leptin concentration in postmenopausal women
AU - Brooks-Asplund, Esther M.
AU - Tupper, Carrie E.
AU - Daun, Jane M.
AU - Kenney, W. Larry
AU - Cannon, Joseph G.
N1 - Funding Information:
This research was supported by National Institutes of Health grants R01 AG07004 and M01 RR10732 as well as an American College of Sports Medicine Foundation Grant.
PY - 2004/2
Y1 - 2004/2
N2 - This investigation examined the influence of hormone replacement therapy on plasma leptin concentrations in postmenopausal women and sought to determine if a relationship existed between plasma leptin, the thermoregulatory cytokine interleukin-1 (IL-1), and basal body temperature. Twenty-two women (54-71 years of age) were studied: eight were not taking hormone replacement, seven took oral estrogen only, and seven took oral estrogen plus progestin. Morning oral temperature, plasma leptin concentration, and mononuclear cell secretion of IL-1β, IL-1 receptor antagonist (IL-1Ra), and soluble IL-1 receptor type II (sIL-1RII) were measured. Plasma leptin concentrations were not affected by hormone replacement therapy, but were inversely related to years since menopause (R=-0.48, P=0.02) and were proportional to IL-1 activity (the balance of IL-1β/IL-1Ra secretion, R=0.69, P=0.001). Moreover, morning oral temperature was positively related to plasma leptin (P=0.03), after stratifying by progestin intake. These results support the concept that basal body temperature is regulated by a network of endocrine and immune mediators that are significantly influenced by age.
AB - This investigation examined the influence of hormone replacement therapy on plasma leptin concentrations in postmenopausal women and sought to determine if a relationship existed between plasma leptin, the thermoregulatory cytokine interleukin-1 (IL-1), and basal body temperature. Twenty-two women (54-71 years of age) were studied: eight were not taking hormone replacement, seven took oral estrogen only, and seven took oral estrogen plus progestin. Morning oral temperature, plasma leptin concentration, and mononuclear cell secretion of IL-1β, IL-1 receptor antagonist (IL-1Ra), and soluble IL-1 receptor type II (sIL-1RII) were measured. Plasma leptin concentrations were not affected by hormone replacement therapy, but were inversely related to years since menopause (R=-0.48, P=0.02) and were proportional to IL-1 activity (the balance of IL-1β/IL-1Ra secretion, R=0.69, P=0.001). Moreover, morning oral temperature was positively related to plasma leptin (P=0.03), after stratifying by progestin intake. These results support the concept that basal body temperature is regulated by a network of endocrine and immune mediators that are significantly influenced by age.
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U2 - 10.1016/j.mad.2003.11.006
DO - 10.1016/j.mad.2003.11.006
M3 - Article
C2 - 15037014
AN - SCOPUS:0842302960
SN - 0047-6374
VL - 125
SP - 117
EP - 119
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 2
ER -