Deubiquitinases in the regulation of NF-κB signaling

Edward W. Harhaj, Vishva M. Dixit

Research output: Contribution to journalReview articlepeer-review

199 Scopus citations


Nuclear factor-kappa B (NF-κB) is a critical regulator of multiple biological functions including innate and adaptive immunity and cell survival. Activation of NF-κB is tightly regulated to preclude chronic signaling that may lead to persistent inflammation and cancer. Ubiquitination of key signaling molecules by E3 ubiquitin ligases has emerged as an important regulatory mechanism for NF-κB signaling. Deubiquitinases (DUBs) counteract E3 ligases and therefore play a prominent role in the downregulation of NF-κB signaling and homeostasis. Understanding the mechanisms of NF-κB downregulation by specific DUBs such as A20 and CYLD may provide therapeutic opportunities for the treatment of chronic inflammatory diseases and cancer.

Original languageEnglish (US)
Pages (from-to)22-39
Number of pages18
JournalCell Research
Issue number1
StatePublished - Jan 2011

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology


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