Development and expansion of high-quality control region databases to improve forensic mtDNA evidence interpretation

  • Jodi A. Irwin
  • , Jessica L. Saunier
  • , Katharine M. Strouss
  • , Kimberly A. Sturk
  • , Toni M. Diegoli
  • , Rebecca S. Just
  • , Michael D. Coble
  • , Walther Parson
  • , Thomas J. Parsons

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

In an effort to increase the quantity, breadth and availability of mtDNA databases suitable for forensic comparisons, we have developed a high-throughput process to generate approximately 5000 control region sequences per year from regional US populations, global populations from which the current US population is derived and global populations currently under-represented in available forensic databases. The system utilizes robotic instrumentation for all laboratory steps from pre-extraction through sequence detection, and a rigorous eight-step, multi-laboratory data review process with entirely electronic data transfer. Over the past 3 years, nearly 10,000 control region sequences have been generated using this approach. These data are being made publicly available and should further address the need for consistent, high-quality mtDNA databases for forensic testing.

Original languageEnglish (US)
Pages (from-to)154-157
Number of pages4
JournalForensic Science International: Genetics
Volume1
Issue number2
DOIs
StatePublished - Jun 2007

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Genetics

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