Development of a wavelet analytical tool for isolating and evaluating cavitation-induced hemolysis generated during mechanical heart valve closure

Cavitation formed during the closure of mechanical heart valves (MHVs) can harm nearby blood cells and valve surfaces. In this study we focus on an approach to accurately measure cavitation energy in order to compare the effectiveness of replacement valves. Cavitation energy is difficult to measure acoustically because it is masked by other pressure fluctuations in the body or system. To improve upon currently used analytical techniques, a wavelet isolation technique was developed to quantify cavitation energy. With this method, acoustic signals captured by a hydrophone are decomposed, denoised, and then reconstructed. Wavelet analysis should prove to be particularly valuable in vivo, where visual evidence of cavitation cannot be obtained.