TY - JOUR
T1 - Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment
T2 - Synthesis and in vivo evaluation in S180-bearing mice
AU - Wang, Yuji
AU - Wei, Lei
AU - Zhao, Ming
AU - Mei, Shenghui
AU - Zheng, Meiqing
AU - Yang, Yifan
AU - Wang, Hong
AU - Chen, Gong
AU - Peng, Shiqi
PY - 2011/11
Y1 - 2011/11
N2 - A series of chelants (3a-s) composed of a glucosyl tail, an amino acid side chain and a dithiocarbamate group were designed, synthesized, and evaluated. By co-administering with cisplatin, 3a-s were able to decrease the accumulation of platinum in the organs, maintain the accumulation of platinum in the tumor tissues, and increase the urinary and fecal platinum, as well as increasing the voided volume of the treated S180-bearing mice. Compared to S180-bearing mice treated with cisplatin alone, the co-administered mice lost no spleen, kidney, liver, brain and heart weights, lost less body weight, and showed no increase in tumor weight.
AB - A series of chelants (3a-s) composed of a glucosyl tail, an amino acid side chain and a dithiocarbamate group were designed, synthesized, and evaluated. By co-administering with cisplatin, 3a-s were able to decrease the accumulation of platinum in the organs, maintain the accumulation of platinum in the tumor tissues, and increase the urinary and fecal platinum, as well as increasing the voided volume of the treated S180-bearing mice. Compared to S180-bearing mice treated with cisplatin alone, the co-administered mice lost no spleen, kidney, liver, brain and heart weights, lost less body weight, and showed no increase in tumor weight.
UR - http://www.scopus.com/inward/record.url?scp=80455163170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80455163170&partnerID=8YFLogxK
U2 - 10.1039/c1mt00013f
DO - 10.1039/c1mt00013f
M3 - Article
C2 - 21584333
AN - SCOPUS:80455163170
SN - 1756-5901
VL - 3
SP - 1212
EP - 1217
JO - Metallomics
JF - Metallomics
IS - 11
ER -