Development of top-down cortical propagations in youth

Adam Pines; Arielle S. Keller; Bart Larsen; Maxwell Bertolero; Arian Ashourvan; Dani S. Bassett; Matthew Cieslak; Sydney Covitz; Yong Fan; Eric Feczko; Audrey Houghton; Amanda R. Rueter; Manish Saggar; Golia Shafiei; Tinashe M. Tapera; Jacob Vogel; Sarah M. Weinstein; Russell T. Shinohara; Leanne M. Williams; Damien A. Fair; Theodore D. Satterthwaite

doi:10.1016/j.neuron.2023.01.014

Development of top-down cortical propagations in youth

Adam Pines, Arielle S. Keller, Bart Larsen, Maxwell Bertolero, Arian Ashourvan, Dani S. Bassett, Matthew Cieslak, Sydney Covitz, Yong Fan, Eric Feczko, Audrey Houghton, Amanda R. Rueter, Manish Saggar, Golia Shafiei, Tinashe M. Tapera, Jacob Vogel, Sarah M. Weinstein, Russell T. Shinohara, Leanne M. Williams, Damien A. FairTheodore D. Satterthwaite

Engineering Science and Mechanics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Hierarchical processing requires activity propagating between higher- and lower-order cortical areas. However, functional neuroimaging studies have chiefly quantified fluctuations within regions over time rather than propagations occurring over space. Here, we leverage advances in neuroimaging and computer vision to track cortical activity propagations in a large sample of youth (n = 388). We delineate cortical propagations that systematically ascend and descend a cortical hierarchy in all individuals in our developmental cohort, as well as in an independent dataset of densely sampled adults. Further, we demonstrate that top-down, descending hierarchical propagations become more prevalent with greater demands for cognitive control as well as with development in youth. These findings emphasize that hierarchical processing is reflected in the directionality of propagating cortical activity and suggest top-down propagations as a potential mechanism of neurocognitive maturation in youth.

Original language	English (US)
Pages (from-to)	1316-1330.e5
Journal	Neuron
Volume	111
Issue number	8
DOIs	https://doi.org/10.1016/j.neuron.2023.01.014
State	Published - Apr 19 2023

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neuron.2023.01.014

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Pines, A., Keller, A. S., Larsen, B., Bertolero, M., Ashourvan, A., Bassett, D. S., Cieslak, M., Covitz, S., Fan, Y., Feczko, E., Houghton, A., Rueter, A. R., Saggar, M., Shafiei, G., Tapera, T. M., Vogel, J., Weinstein, S. M., Shinohara, R. T., Williams, L. M., ... Satterthwaite, T. D. (2023). Development of top-down cortical propagations in youth. Neuron, 111(8), 1316-1330.e5. https://doi.org/10.1016/j.neuron.2023.01.014

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title = "Development of top-down cortical propagations in youth",

abstract = "Hierarchical processing requires activity propagating between higher- and lower-order cortical areas. However, functional neuroimaging studies have chiefly quantified fluctuations within regions over time rather than propagations occurring over space. Here, we leverage advances in neuroimaging and computer vision to track cortical activity propagations in a large sample of youth (n = 388). We delineate cortical propagations that systematically ascend and descend a cortical hierarchy in all individuals in our developmental cohort, as well as in an independent dataset of densely sampled adults. Further, we demonstrate that top-down, descending hierarchical propagations become more prevalent with greater demands for cognitive control as well as with development in youth. These findings emphasize that hierarchical processing is reflected in the directionality of propagating cortical activity and suggest top-down propagations as a potential mechanism of neurocognitive maturation in youth.",

author = "Adam Pines and Keller, {Arielle S.} and Bart Larsen and Maxwell Bertolero and Arian Ashourvan and Bassett, {Dani S.} and Matthew Cieslak and Sydney Covitz and Yong Fan and Eric Feczko and Audrey Houghton and Rueter, {Amanda R.} and Manish Saggar and Golia Shafiei and Tapera, {Tinashe M.} and Jacob Vogel and Weinstein, {Sarah M.} and Shinohara, {Russell T.} and Williams, {Leanne M.} and Fair, {Damien A.} and Satterthwaite, {Theodore D.}",

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doi = "10.1016/j.neuron.2023.01.014",

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Pines, A, Keller, AS, Larsen, B, Bertolero, M, Ashourvan, A, Bassett, DS, Cieslak, M, Covitz, S, Fan, Y, Feczko, E, Houghton, A, Rueter, AR, Saggar, M, Shafiei, G, Tapera, TM, Vogel, J, Weinstein, SM, Shinohara, RT, Williams, LM, Fair, DA & Satterthwaite, TD 2023, 'Development of top-down cortical propagations in youth', Neuron, vol. 111, no. 8, pp. 1316-1330.e5. https://doi.org/10.1016/j.neuron.2023.01.014

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AU - Pines, Adam

AU - Keller, Arielle S.

AU - Larsen, Bart

AU - Bertolero, Maxwell

AU - Ashourvan, Arian

AU - Bassett, Dani S.

AU - Cieslak, Matthew

AU - Covitz, Sydney

AU - Fan, Yong

AU - Feczko, Eric

AU - Houghton, Audrey

AU - Rueter, Amanda R.

AU - Saggar, Manish

AU - Shafiei, Golia

AU - Tapera, Tinashe M.

AU - Vogel, Jacob

AU - Weinstein, Sarah M.

AU - Shinohara, Russell T.

AU - Williams, Leanne M.

AU - Fair, Damien A.

AU - Satterthwaite, Theodore D.

PY - 2023/4/19

Y1 - 2023/4/19

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AB - Hierarchical processing requires activity propagating between higher- and lower-order cortical areas. However, functional neuroimaging studies have chiefly quantified fluctuations within regions over time rather than propagations occurring over space. Here, we leverage advances in neuroimaging and computer vision to track cortical activity propagations in a large sample of youth (n = 388). We delineate cortical propagations that systematically ascend and descend a cortical hierarchy in all individuals in our developmental cohort, as well as in an independent dataset of densely sampled adults. Further, we demonstrate that top-down, descending hierarchical propagations become more prevalent with greater demands for cognitive control as well as with development in youth. These findings emphasize that hierarchical processing is reflected in the directionality of propagating cortical activity and suggest top-down propagations as a potential mechanism of neurocognitive maturation in youth.

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ER -

Development of top-down cortical propagations in youth

Abstract

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