TY - JOUR
T1 - Developmental aspects of the upper airway
T2 - Report from an NHLBI Workshop, March 5-6, 2009
AU - Marcus, Carole L.
AU - Smith, Richard J.H.
AU - Mankarious, Leila A.
AU - Arens, Raanan
AU - Mitchell, Gordon S.
AU - Elluru, Ravindhra G.
AU - Forte, Vito
AU - Goudy, Steven
AU - Jabs, Ethylin W.
AU - Kane, Alex A.
AU - Katz, Eliot
AU - Paydarfar, David
AU - Pereira, Kevin
AU - Reeves, Roger H.
AU - Richtsmeier, Joan T.
AU - Ruiz, Ramon L.
AU - Thach, Bradley T.
AU - Tunkel, David E.
AU - Whitsett, Jeffrey A.
AU - Wootton, David
AU - Blaisdell, Carol J.
PY - 2009/9/15
Y1 - 2009/9/15
N2 - The upper airway serves three important functions: respiration, swallowing, andspeech.Duringdevelopment itundergoes significant structural and functional changes that affect its size, shape, and mechanical properties. Abnormalities of the upper airway require prompt attention, because these often alter ventilatory patterns and gas exchange, particularly during sleep when upper airway motor tone and ventilatory drive are diminished. Recognizing the relationship of early life events to lung health and disease, theNationalHeart, Lung, and Blood Institute (NHLBI), with cofunding fromthe Office of Rare Diseases (ORD), convened a workshop of extramural experts, from many disciplines. The objective of the workshop was: (1) to review the state of science in pediatric upper airway disorders; (2) to make recommendations to the Institute to fill knowledge gaps; (3) to prioritize new research directions; and (4) to capitalize on scientific opportunities. This report provides recommendations that could facilitate translation of basic research findings into practice to better diagnose, treat, and prevent airway compromise in children.
AB - The upper airway serves three important functions: respiration, swallowing, andspeech.Duringdevelopment itundergoes significant structural and functional changes that affect its size, shape, and mechanical properties. Abnormalities of the upper airway require prompt attention, because these often alter ventilatory patterns and gas exchange, particularly during sleep when upper airway motor tone and ventilatory drive are diminished. Recognizing the relationship of early life events to lung health and disease, theNationalHeart, Lung, and Blood Institute (NHLBI), with cofunding fromthe Office of Rare Diseases (ORD), convened a workshop of extramural experts, from many disciplines. The objective of the workshop was: (1) to review the state of science in pediatric upper airway disorders; (2) to make recommendations to the Institute to fill knowledge gaps; (3) to prioritize new research directions; and (4) to capitalize on scientific opportunities. This report provides recommendations that could facilitate translation of basic research findings into practice to better diagnose, treat, and prevent airway compromise in children.
UR - http://www.scopus.com/inward/record.url?scp=70349109630&partnerID=8YFLogxK
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U2 - 10.1513/pats.200905-024CB
DO - 10.1513/pats.200905-024CB
M3 - Article
C2 - 19741259
AN - SCOPUS:70349109630
SN - 1546-3222
VL - 6
SP - 513
EP - 520
JO - Proceedings of the American Thoracic Society
JF - Proceedings of the American Thoracic Society
IS - 6
ER -