TY - JOUR
T1 - Developmental expression of neuronal calmodulin-binding proteins in rat brain
AU - Polli, Joseph W.
AU - Patanow, Christine M.
AU - Billingsley, Melvin L.
N1 - Funding Information:
Acknowledgements. We thankD rs. RandallK incaid, George Oylera ndKyle Kradyf or their helapn ds uggestiodnus ringth is work.T hisw orkw ass upported by a PharmaceMuatnicuafla cturers AssociatioPnr edoctoral FellowshiJp.W to.P ., and research grants from the InternatioLnifaelS ciences Institute Research Foundation, PHS RO-AG06377a,n dA CS GrantI N-109Jt o M.L.B.
PY - 1990/4/1
Y1 - 1990/4/1
N2 - The developmental patterns of calmodulin-binding proteins (CaM-BPS) in rat brain were examined using biotinylated calmodulin overlays of one- and two-dimensional gels. Hippocampus showed the earliest onset of CaM-BP expression (postnatal day 5; PND5), followed by cerebral cortex and striatum, both of which had detectable levels of CaM-BPs by PND7. Cerebellum had the latest onset of CaM-BP expression; CaM-BPs were not detectable until PND9. Very few CaM-BPs were present in brain before PND5 and all regions reached near adult levels by PND20. However, several unique CaM-BPs were seen in embryonic brain and these proteins may have an important role in developing neurons. These data suggest an orderly, complex expression of CaM-BPs which increases during times of synaptogenesis and synaptic maturation.
AB - The developmental patterns of calmodulin-binding proteins (CaM-BPS) in rat brain were examined using biotinylated calmodulin overlays of one- and two-dimensional gels. Hippocampus showed the earliest onset of CaM-BP expression (postnatal day 5; PND5), followed by cerebral cortex and striatum, both of which had detectable levels of CaM-BPs by PND7. Cerebellum had the latest onset of CaM-BP expression; CaM-BPs were not detectable until PND9. Very few CaM-BPs were present in brain before PND5 and all regions reached near adult levels by PND20. However, several unique CaM-BPs were seen in embryonic brain and these proteins may have an important role in developing neurons. These data suggest an orderly, complex expression of CaM-BPs which increases during times of synaptogenesis and synaptic maturation.
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U2 - 10.1016/0165-3806(90)90124-H
DO - 10.1016/0165-3806(90)90124-H
M3 - Article
C2 - 2350882
AN - SCOPUS:0025343541
SN - 0165-3806
VL - 53
SP - 62
EP - 70
JO - Developmental Brain Research
JF - Developmental Brain Research
IS - 1
ER -