Developmental expression of neuronal calmodulin-binding proteins in rat brain

Joseph W. Polli; Christine M. Patanow; Melvin L. Billingsley

doi:10.1016/0165-3806(90)90124-H

Developmental expression of neuronal calmodulin-binding proteins in rat brain

Joseph W. Polli
, Christine M. Patanow
, Melvin L. Billingsley

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The developmental patterns of calmodulin-binding proteins (CaM-BPS) in rat brain were examined using biotinylated calmodulin overlays of one- and two-dimensional gels. Hippocampus showed the earliest onset of CaM-BP expression (postnatal day 5; PND5), followed by cerebral cortex and striatum, both of which had detectable levels of CaM-BPs by PND7. Cerebellum had the latest onset of CaM-BP expression; CaM-BPs were not detectable until PND9. Very few CaM-BPs were present in brain before PND5 and all regions reached near adult levels by PND20. However, several unique CaM-BPs were seen in embryonic brain and these proteins may have an important role in developing neurons. These data suggest an orderly, complex expression of CaM-BPs which increases during times of synaptogenesis and synaptic maturation.

Original language	English (US)
Pages (from-to)	62-70
Number of pages	9
Journal	Developmental Brain Research
Volume	53
Issue number	1
DOIs	https://doi.org/10.1016/0165-3806(90)90124-H
State	Published - Apr 1 1990

All Science Journal Classification (ASJC) codes

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(90)90124-H

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@article{6269cb271015438b82d7ffa8af9f8d3a,

title = "Developmental expression of neuronal calmodulin-binding proteins in rat brain",

abstract = "The developmental patterns of calmodulin-binding proteins (CaM-BPS) in rat brain were examined using biotinylated calmodulin overlays of one- and two-dimensional gels. Hippocampus showed the earliest onset of CaM-BP expression (postnatal day 5; PND5), followed by cerebral cortex and striatum, both of which had detectable levels of CaM-BPs by PND7. Cerebellum had the latest onset of CaM-BP expression; CaM-BPs were not detectable until PND9. Very few CaM-BPs were present in brain before PND5 and all regions reached near adult levels by PND20. However, several unique CaM-BPs were seen in embryonic brain and these proteins may have an important role in developing neurons. These data suggest an orderly, complex expression of CaM-BPs which increases during times of synaptogenesis and synaptic maturation.",

author = "Polli, \{Joseph W.\} and Patanow, \{Christine M.\} and Billingsley, \{Melvin L.\}",

note = "Funding Information: Acknowledgements. We thankD rs. RandallK incaid, George Oylera ndKyle Kradyf or their helapn ds uggestiodnus ringth is work.T hisw orkw ass upported by a PharmaceMuatnicuafla cturers AssociatioPnr edoctoral FellowshiJp.W to.P ., and research grants from the InternatioLnifaelS ciences Institute Research Foundation, PHS RO-AG06377a,n dA CS GrantI N-109Jt o M.L.B.",

year = "1990",

month = apr,

day = "1",

doi = "10.1016/0165-3806(90)90124-H",

language = "English (US)",

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pages = "62--70",

journal = "Developmental Brain Research",

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T1 - Developmental expression of neuronal calmodulin-binding proteins in rat brain

AU - Polli, Joseph W.

AU - Patanow, Christine M.

AU - Billingsley, Melvin L.

N1 - Funding Information: Acknowledgements. We thankD rs. RandallK incaid, George Oylera ndKyle Kradyf or their helapn ds uggestiodnus ringth is work.T hisw orkw ass upported by a PharmaceMuatnicuafla cturers AssociatioPnr edoctoral FellowshiJp.W to.P ., and research grants from the InternatioLnifaelS ciences Institute Research Foundation, PHS RO-AG06377a,n dA CS GrantI N-109Jt o M.L.B.

PY - 1990/4/1

Y1 - 1990/4/1

N2 - The developmental patterns of calmodulin-binding proteins (CaM-BPS) in rat brain were examined using biotinylated calmodulin overlays of one- and two-dimensional gels. Hippocampus showed the earliest onset of CaM-BP expression (postnatal day 5; PND5), followed by cerebral cortex and striatum, both of which had detectable levels of CaM-BPs by PND7. Cerebellum had the latest onset of CaM-BP expression; CaM-BPs were not detectable until PND9. Very few CaM-BPs were present in brain before PND5 and all regions reached near adult levels by PND20. However, several unique CaM-BPs were seen in embryonic brain and these proteins may have an important role in developing neurons. These data suggest an orderly, complex expression of CaM-BPs which increases during times of synaptogenesis and synaptic maturation.

AB - The developmental patterns of calmodulin-binding proteins (CaM-BPS) in rat brain were examined using biotinylated calmodulin overlays of one- and two-dimensional gels. Hippocampus showed the earliest onset of CaM-BP expression (postnatal day 5; PND5), followed by cerebral cortex and striatum, both of which had detectable levels of CaM-BPs by PND7. Cerebellum had the latest onset of CaM-BP expression; CaM-BPs were not detectable until PND9. Very few CaM-BPs were present in brain before PND5 and all regions reached near adult levels by PND20. However, several unique CaM-BPs were seen in embryonic brain and these proteins may have an important role in developing neurons. These data suggest an orderly, complex expression of CaM-BPs which increases during times of synaptogenesis and synaptic maturation.

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DO - 10.1016/0165-3806(90)90124-H

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Developmental expression of neuronal calmodulin-binding proteins in rat brain

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