Developmental psychopathology of children and adolescents with Tourette syndrome - Impact of ADHD

Veit Roessner; Andreas Becker; Tobias Banaschewski; Roger D. Freeman; Aribert Rothenberger; Henrik Aabech; Javad Allaghband-Rad; Cheston Berlin; Ruth Bruun; Cathy Budman; Larry Burd; Francesco Cardona; Francisco Cardoso; Jose Castillo; Susan Chien; Sylvain Chouinard; Yves Dion; Jacques Eisenberg; Nihal Erfan; Diane Fast; John Fayyed; Emilio Fernandez-Alvarez; Ken Gadow; Oscar Gershanik; Michel Gil; Don Gilbert; Helga Hannesdottir; Don Higgins; Piotr Janik; Joseph Jankovic; Bjorn Kadesjo; Yukiko Kano; Jacob Kerbeshian; Abraham Kessler; U. Finn Knudsen; Anne Korsgaard; Anthony Lang; David Lichter; Trygve Lindback; Zhisheng Liu; Danielle Lobel; Alida Magor; Euripides Miguel; Kirsten Mueller-Vahl; Kieran O'Connor; Jessica Oesterheld; Larry Pancer; Hugh Rickards; Mary Robertson; Jeffrey Rubin; Evzen Ruzicka; Kim St. John; Paul Sandor; Anton Scamvougeras; Gary Shady; Miriam Spinner; Mara Stamenkovic; Jeffrey Sverd; Zsanett Tarnok; Chris Van Der Linden; Arja Voutilainen; Yanki Yazgan; Zheng Yi; Sam Zinner

doi:10.1007/s00787-007-1004-6

Developmental psychopathology of children and adolescents with Tourette syndrome - Impact of ADHD

Veit Roessner, Andreas Becker, Tobias Banaschewski, Roger D. Freeman, Aribert Rothenberger, Henrik Aabech, Javad Allaghband-Rad, Cheston Berlin, Ruth Bruun, Cathy Budman, Larry Burd, Francesco Cardona, Francisco Cardoso, Jose Castillo, Susan Chien, Sylvain Chouinard, Yves Dion, Jacques Eisenberg, Nihal Erfan, Diane FastJohn Fayyed, Emilio Fernandez-Alvarez, Ken Gadow, Oscar Gershanik, Michel Gil, Don Gilbert, Helga Hannesdottir, Don Higgins, Piotr Janik, Joseph Jankovic, Bjorn Kadesjo, Yukiko Kano, Jacob Kerbeshian, Abraham Kessler, U. Finn Knudsen, Anne Korsgaard, Anthony Lang, David Lichter, Trygve Lindback, Zhisheng Liu, Danielle Lobel, Alida Magor, Euripides Miguel, Kirsten Mueller-Vahl, Kieran O'Connor, Jessica Oesterheld, Larry Pancer, Hugh Rickards, Mary Robertson, Jeffrey Rubin, Evzen Ruzicka, Kim St. John, Paul Sandor, Anton Scamvougeras, Gary Shady, Miriam Spinner, Mara Stamenkovic, Jeffrey Sverd, Zsanett Tarnok, Chris Van Der Linden, Arja Voutilainen, Yanki Yazgan, Zheng Yi, Sam Zinner

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Abstract

Background: In Tourette syndrome (TS) as a neurodevelopmental disorder not only the tics but also the comorbid conditions change with increasing age. ADHD is highly comorbid with TS and usually impairs psychosocial functioning more than the tics. Its impact on further comorbidity during development is important for clinical practice and still a matter of debate. Method: Aspects of developmental psychopathology considering the impact of ADHD were examined by logistic regression (year wisely) in a cross-sectional sample of children and adolescents (n = 5060) from the TIC database. Results: In TS+ADHD (compared to TS-ADHD) higher rates of comorbid conditions like OCD, anxiety disorders, CD/ODD and mood disorders were found in children (5-10 years). In adolescents (11-17 years) higher comorbidity rates in TS+ADHD remained only for CD/ODD and mood disorders. Accordingly, for OCD and anxiety disorders there was a steeper year wise increase of these comorbidities in TS-ADHD while it was a similar for CD/ODD and mood disorders in TS-ADHD as well as TS+ADHD. Conclusion: Children with TS+ADHD have more comorbidities than the TS-ADHD group, whereas in both adolescent groups this did no longer hold for OCD and anxiety disorders. These findings indicate that in TS comorbid ADHD is associated with high rates of externalizing and internalizing problems, whereas TS without ADHD is associated only with internalizing problems in adolescence.

Original language	English (US)
Pages (from-to)	I/24-I/35
Journal	European Child and Adolescent Psychiatry
Volume	16
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1007/s00787-007-1004-6
State	Published - Jul 2007

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Developmental and Educational Psychology
Psychiatry and Mental health

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10.1007/s00787-007-1004-6

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Roessner, V., Becker, A., Banaschewski, T., Freeman, R. D., Rothenberger, A., Aabech, H., Allaghband-Rad, J., Berlin, C., Bruun, R., Budman, C., Burd, L., Cardona, F., Cardoso, F., Castillo, J., Chien, S., Chouinard, S., Dion, Y., Eisenberg, J., Erfan, N., ... Zinner, S. (2007). Developmental psychopathology of children and adolescents with Tourette syndrome - Impact of ADHD. European Child and Adolescent Psychiatry, 16(SUPPL. 1), I/24-I/35. https://doi.org/10.1007/s00787-007-1004-6

@article{570ef3f3897d45f3913961d460c2f1a1,

title = "Developmental psychopathology of children and adolescents with Tourette syndrome - Impact of ADHD",

abstract = "Background: In Tourette syndrome (TS) as a neurodevelopmental disorder not only the tics but also the comorbid conditions change with increasing age. ADHD is highly comorbid with TS and usually impairs psychosocial functioning more than the tics. Its impact on further comorbidity during development is important for clinical practice and still a matter of debate. Method: Aspects of developmental psychopathology considering the impact of ADHD were examined by logistic regression (year wisely) in a cross-sectional sample of children and adolescents (n = 5060) from the TIC database. Results: In TS+ADHD (compared to TS-ADHD) higher rates of comorbid conditions like OCD, anxiety disorders, CD/ODD and mood disorders were found in children (5-10 years). In adolescents (11-17 years) higher comorbidity rates in TS+ADHD remained only for CD/ODD and mood disorders. Accordingly, for OCD and anxiety disorders there was a steeper year wise increase of these comorbidities in TS-ADHD while it was a similar for CD/ODD and mood disorders in TS-ADHD as well as TS+ADHD. Conclusion: Children with TS+ADHD have more comorbidities than the TS-ADHD group, whereas in both adolescent groups this did no longer hold for OCD and anxiety disorders. These findings indicate that in TS comorbid ADHD is associated with high rates of externalizing and internalizing problems, whereas TS without ADHD is associated only with internalizing problems in adolescence.",

author = "Veit Roessner and Andreas Becker and Tobias Banaschewski and Freeman, {Roger D.} and Aribert Rothenberger and Henrik Aabech and Javad Allaghband-Rad and Cheston Berlin and Ruth Bruun and Cathy Budman and Larry Burd and Francesco Cardona and Francisco Cardoso and Jose Castillo and Susan Chien and Sylvain Chouinard and Yves Dion and Jacques Eisenberg and Nihal Erfan and Diane Fast and John Fayyed and Emilio Fernandez-Alvarez and Ken Gadow and Oscar Gershanik and Michel Gil and Don Gilbert and Helga Hannesdottir and Don Higgins and Piotr Janik and Joseph Jankovic and Bjorn Kadesjo and Yukiko Kano and Jacob Kerbeshian and Abraham Kessler and Knudsen, {U. Finn} and Anne Korsgaard and Anthony Lang and David Lichter and Trygve Lindback and Zhisheng Liu and Danielle Lobel and Alida Magor and Euripides Miguel and Kirsten Mueller-Vahl and Kieran O'Connor and Jessica Oesterheld and Larry Pancer and Hugh Rickards and Mary Robertson and Jeffrey Rubin and Evzen Ruzicka and {St. John}, Kim and Paul Sandor and Anton Scamvougeras and Gary Shady and Miriam Spinner and Mara Stamenkovic and Jeffrey Sverd and Zsanett Tarnok and {Van Der Linden}, Chris and Arja Voutilainen and Yanki Yazgan and Zheng Yi and Sam Zinner",

year = "2007",

month = jul,

doi = "10.1007/s00787-007-1004-6",

language = "English (US)",

volume = "16",

pages = "I/24--I/35",

journal = "European Child and Adolescent Psychiatry",

issn = "1018-8827",

publisher = "D. Steinkopff-Verlag",

number = "SUPPL. 1",

}

Roessner, V, Becker, A, Banaschewski, T, Freeman, RD, Rothenberger, A, Aabech, H, Allaghband-Rad, J, Berlin, C, Bruun, R, Budman, C, Burd, L, Cardona, F, Cardoso, F, Castillo, J, Chien, S, Chouinard, S, Dion, Y, Eisenberg, J, Erfan, N, Fast, D, Fayyed, J, Fernandez-Alvarez, E, Gadow, K, Gershanik, O, Gil, M, Gilbert, D, Hannesdottir, H, Higgins, D, Janik, P, Jankovic, J, Kadesjo, B, Kano, Y, Kerbeshian, J, Kessler, A, Knudsen, UF, Korsgaard, A, Lang, A, Lichter, D, Lindback, T, Liu, Z, Lobel, D, Magor, A, Miguel, E, Mueller-Vahl, K, O'Connor, K, Oesterheld, J, Pancer, L, Rickards, H, Robertson, M, Rubin, J, Ruzicka, E, St. John, K, Sandor, P, Scamvougeras, A, Shady, G, Spinner, M, Stamenkovic, M, Sverd, J, Tarnok, Z, Van Der Linden, C, Voutilainen, A, Yazgan, Y, Yi, Z & Zinner, S 2007, 'Developmental psychopathology of children and adolescents with Tourette syndrome - Impact of ADHD', European Child and Adolescent Psychiatry, vol. 16, no. SUPPL. 1, pp. I/24-I/35. https://doi.org/10.1007/s00787-007-1004-6

TY - JOUR

T1 - Developmental psychopathology of children and adolescents with Tourette syndrome - Impact of ADHD

AU - Roessner, Veit

AU - Becker, Andreas

AU - Banaschewski, Tobias

AU - Freeman, Roger D.

AU - Rothenberger, Aribert

AU - Aabech, Henrik

AU - Allaghband-Rad, Javad

AU - Berlin, Cheston

AU - Bruun, Ruth

AU - Budman, Cathy

AU - Burd, Larry

AU - Cardona, Francesco

AU - Cardoso, Francisco

AU - Castillo, Jose

AU - Chien, Susan

AU - Chouinard, Sylvain

AU - Dion, Yves

AU - Eisenberg, Jacques

AU - Erfan, Nihal

AU - Fast, Diane

AU - Fayyed, John

AU - Fernandez-Alvarez, Emilio

AU - Gadow, Ken

AU - Gershanik, Oscar

AU - Gil, Michel

AU - Gilbert, Don

AU - Hannesdottir, Helga

AU - Higgins, Don

AU - Janik, Piotr

AU - Jankovic, Joseph

AU - Kadesjo, Bjorn

AU - Kano, Yukiko

AU - Kerbeshian, Jacob

AU - Kessler, Abraham

AU - Knudsen, U. Finn

AU - Korsgaard, Anne

AU - Lang, Anthony

AU - Lichter, David

AU - Lindback, Trygve

AU - Liu, Zhisheng

AU - Lobel, Danielle

AU - Magor, Alida

AU - Miguel, Euripides

AU - Mueller-Vahl, Kirsten

AU - O'Connor, Kieran

AU - Oesterheld, Jessica

AU - Pancer, Larry

AU - Rickards, Hugh

AU - Robertson, Mary

AU - Rubin, Jeffrey

AU - Ruzicka, Evzen

AU - St. John, Kim

AU - Sandor, Paul

AU - Scamvougeras, Anton

AU - Shady, Gary

AU - Spinner, Miriam

AU - Stamenkovic, Mara

AU - Sverd, Jeffrey

AU - Tarnok, Zsanett

AU - Van Der Linden, Chris

AU - Voutilainen, Arja

AU - Yazgan, Yanki

AU - Yi, Zheng

AU - Zinner, Sam

PY - 2007/7

Y1 - 2007/7

N2 - Background: In Tourette syndrome (TS) as a neurodevelopmental disorder not only the tics but also the comorbid conditions change with increasing age. ADHD is highly comorbid with TS and usually impairs psychosocial functioning more than the tics. Its impact on further comorbidity during development is important for clinical practice and still a matter of debate. Method: Aspects of developmental psychopathology considering the impact of ADHD were examined by logistic regression (year wisely) in a cross-sectional sample of children and adolescents (n = 5060) from the TIC database. Results: In TS+ADHD (compared to TS-ADHD) higher rates of comorbid conditions like OCD, anxiety disorders, CD/ODD and mood disorders were found in children (5-10 years). In adolescents (11-17 years) higher comorbidity rates in TS+ADHD remained only for CD/ODD and mood disorders. Accordingly, for OCD and anxiety disorders there was a steeper year wise increase of these comorbidities in TS-ADHD while it was a similar for CD/ODD and mood disorders in TS-ADHD as well as TS+ADHD. Conclusion: Children with TS+ADHD have more comorbidities than the TS-ADHD group, whereas in both adolescent groups this did no longer hold for OCD and anxiety disorders. These findings indicate that in TS comorbid ADHD is associated with high rates of externalizing and internalizing problems, whereas TS without ADHD is associated only with internalizing problems in adolescence.

AB - Background: In Tourette syndrome (TS) as a neurodevelopmental disorder not only the tics but also the comorbid conditions change with increasing age. ADHD is highly comorbid with TS and usually impairs psychosocial functioning more than the tics. Its impact on further comorbidity during development is important for clinical practice and still a matter of debate. Method: Aspects of developmental psychopathology considering the impact of ADHD were examined by logistic regression (year wisely) in a cross-sectional sample of children and adolescents (n = 5060) from the TIC database. Results: In TS+ADHD (compared to TS-ADHD) higher rates of comorbid conditions like OCD, anxiety disorders, CD/ODD and mood disorders were found in children (5-10 years). In adolescents (11-17 years) higher comorbidity rates in TS+ADHD remained only for CD/ODD and mood disorders. Accordingly, for OCD and anxiety disorders there was a steeper year wise increase of these comorbidities in TS-ADHD while it was a similar for CD/ODD and mood disorders in TS-ADHD as well as TS+ADHD. Conclusion: Children with TS+ADHD have more comorbidities than the TS-ADHD group, whereas in both adolescent groups this did no longer hold for OCD and anxiety disorders. These findings indicate that in TS comorbid ADHD is associated with high rates of externalizing and internalizing problems, whereas TS without ADHD is associated only with internalizing problems in adolescence.

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U2 - 10.1007/s00787-007-1004-6

DO - 10.1007/s00787-007-1004-6

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AN - SCOPUS:34547829241

SN - 1018-8827

VL - 16

SP - I/24-I/35

JO - European Child and Adolescent Psychiatry

JF - European Child and Adolescent Psychiatry

IS - SUPPL. 1

ER -

Developmental psychopathology of children and adolescents with Tourette syndrome - Impact of ADHD

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