TY - JOUR
T1 - Developmental trajectories of children with birth asphyxia through 36months of age in low/low-middle income countries
AU - Wallander, Jan L.
AU - Bann, Carla
AU - Chomba, Elwyn
AU - Goudar, Shivaprasad S.
AU - Pasha, Omrana
AU - Biasini, Fred J.
AU - McClure, Elizabeth M.
AU - Thorsten, Vanessa
AU - Wallace, Dennis
AU - Carlo, Waldemar A.
N1 - Funding Information:
The Eunice Kennedy Shriver National Institute of Child Health and Human Development , the National Institute of Neurological Disorders and Stroke ( HD43464 , HD42372 , HD40607 , and HD40636 ), the Fogarty International Center ( TW006703 ), the Perinatal Health and Human Development Research Program , and the Children's of Alabama Centennial Scholar Fund of the University of Alabama at Birmingham funded this research. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health (NIH); NIH staff who contributed to the design of the study and collection of the data, but not in the analysis, preparation, review, or approval of the manuscript, or decision to submit the manuscript.
Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2014
Y1 - 2014
N2 - Background: Resuscitation following birth asphyxia reduces mortality, but may be argued to increase risk for neurodevelopmental disability in survivors. Aims: To test the hypothesis that development of infants who received resuscitation following birth asphyxia is not significantly different through 36. months of age from infants who had healthy births. Study design: Prospective observational cohort design comparing infants exposed to birth asphyxia with resuscitation or healthy birth. Subjects: A random sample of infants with birth asphyxia who received bag-and-mask resuscitation was selected from birth records in selected communities in 3 countries. Exclusion criteria: birth weight. <. 1500. g, severely abnormal neurological examination at 7. days, mother. <. 15. years, unable to participate, or not expected to remain in the target area. A random sample of healthy-birth infants (no resuscitation, normal neurological exam) was also selected. Eligible. =. 438, consented. =. 407, and ≥. 1 valid developmental assessment during the first 36. months. =. 376. Outcome measure(s): Bayley Scales of Infant Development-II Mental (MDI) and Psychomotor (PDI) Development Index. Results: Trajectories of MDI (p. =. .069) and PDI (p. =. .143) over 3 yearly assessments did not differ between children with birth asphyxia and healthy-birth children. Rather there was a trend for birth asphyxia children to improve more than healthy-birth children. Conclusions: The large majority of infants who are treated with resuscitation and survived birth asphyxia can be expected to evidence normal development at least until age 3. The risk for neurodevelopmental disability should not justify the restriction of effective therapies for birth asphyxia.
AB - Background: Resuscitation following birth asphyxia reduces mortality, but may be argued to increase risk for neurodevelopmental disability in survivors. Aims: To test the hypothesis that development of infants who received resuscitation following birth asphyxia is not significantly different through 36. months of age from infants who had healthy births. Study design: Prospective observational cohort design comparing infants exposed to birth asphyxia with resuscitation or healthy birth. Subjects: A random sample of infants with birth asphyxia who received bag-and-mask resuscitation was selected from birth records in selected communities in 3 countries. Exclusion criteria: birth weight. <. 1500. g, severely abnormal neurological examination at 7. days, mother. <. 15. years, unable to participate, or not expected to remain in the target area. A random sample of healthy-birth infants (no resuscitation, normal neurological exam) was also selected. Eligible. =. 438, consented. =. 407, and ≥. 1 valid developmental assessment during the first 36. months. =. 376. Outcome measure(s): Bayley Scales of Infant Development-II Mental (MDI) and Psychomotor (PDI) Development Index. Results: Trajectories of MDI (p. =. .069) and PDI (p. =. .143) over 3 yearly assessments did not differ between children with birth asphyxia and healthy-birth children. Rather there was a trend for birth asphyxia children to improve more than healthy-birth children. Conclusions: The large majority of infants who are treated with resuscitation and survived birth asphyxia can be expected to evidence normal development at least until age 3. The risk for neurodevelopmental disability should not justify the restriction of effective therapies for birth asphyxia.
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U2 - 10.1016/j.earlhumdev.2014.04.013
DO - 10.1016/j.earlhumdev.2014.04.013
M3 - Article
C2 - 24815056
AN - SCOPUS:84925225924
SN - 0378-3782
VL - 90
SP - 343
EP - 348
JO - Early Human Development
JF - Early Human Development
IS - 7
ER -