Dextro-amphetamine increases phosphoinositol cycle activity in volunteers: An MRS study

Peter H. Silverstone; Tina O'Donnell; Michele Ulrich; Sheila Asghar; Christopher C. Hanstock

doi:10.1002/hup.434

Dextro-amphetamine increases phosphoinositol cycle activity in volunteers: An MRS study

Peter H. Silverstone, Tina O'Donnell, Michele Ulrich, Sheila Asghar, Christopher C. Hanstock

Department of Pediatrics

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Aims. To help determine the effects of dextro-amphetamine on the phosphoinositol cycle (PI-cycle) in humans, ¹H and ³¹P magnetic resonance spectroscopy (MRS) was utilized in 17 healthy volunteers. This was an open-label study carried out before and after administration of 20mg oral dextro-amphetamine. Subjects also rated the subjective effects of dextro-amphetamine administration using visual analog scales (VAS). Major findings. Following dextro-amphetamine administration there was a significant increase in the concentrations of both myo-inositol and phosphomonoesters. Conclusions. These findings are in keeping with suggestions that dextro-amphetamine administration increases the activity of the phosphoinositol cycle, probably via an indirect release of dopamine and noradrenaline. These results are the first time that this has been confirmed in humans.

Original language	English (US)
Pages (from-to)	425-429
Number of pages	5
Journal	Human Psychopharmacology
Volume	17
Issue number	8
DOIs	https://doi.org/10.1002/hup.434
State	Published - Dec 2002

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Psychiatry and Mental health
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hup.434

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title = "Dextro-amphetamine increases phosphoinositol cycle activity in volunteers: An MRS study",

abstract = "Aims. To help determine the effects of dextro-amphetamine on the phosphoinositol cycle (PI-cycle) in humans, 1H and 31P magnetic resonance spectroscopy (MRS) was utilized in 17 healthy volunteers. This was an open-label study carried out before and after administration of 20mg oral dextro-amphetamine. Subjects also rated the subjective effects of dextro-amphetamine administration using visual analog scales (VAS). Major findings. Following dextro-amphetamine administration there was a significant increase in the concentrations of both myo-inositol and phosphomonoesters. Conclusions. These findings are in keeping with suggestions that dextro-amphetamine administration increases the activity of the phosphoinositol cycle, probably via an indirect release of dopamine and noradrenaline. These results are the first time that this has been confirmed in humans.",

author = "Silverstone, {Peter H.} and Tina O'Donnell and Michele Ulrich and Sheila Asghar and Hanstock, {Christopher C.}",

year = "2002",

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doi = "10.1002/hup.434",

language = "English (US)",

volume = "17",

pages = "425--429",

journal = "Human Psychopharmacology",

issn = "0885-6222",

publisher = "John Wiley and Sons Ltd",

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T1 - Dextro-amphetamine increases phosphoinositol cycle activity in volunteers

T2 - An MRS study

AU - Silverstone, Peter H.

AU - O'Donnell, Tina

AU - Ulrich, Michele

AU - Asghar, Sheila

AU - Hanstock, Christopher C.

PY - 2002/12

Y1 - 2002/12

N2 - Aims. To help determine the effects of dextro-amphetamine on the phosphoinositol cycle (PI-cycle) in humans, 1H and 31P magnetic resonance spectroscopy (MRS) was utilized in 17 healthy volunteers. This was an open-label study carried out before and after administration of 20mg oral dextro-amphetamine. Subjects also rated the subjective effects of dextro-amphetamine administration using visual analog scales (VAS). Major findings. Following dextro-amphetamine administration there was a significant increase in the concentrations of both myo-inositol and phosphomonoesters. Conclusions. These findings are in keeping with suggestions that dextro-amphetamine administration increases the activity of the phosphoinositol cycle, probably via an indirect release of dopamine and noradrenaline. These results are the first time that this has been confirmed in humans.

AB - Aims. To help determine the effects of dextro-amphetamine on the phosphoinositol cycle (PI-cycle) in humans, 1H and 31P magnetic resonance spectroscopy (MRS) was utilized in 17 healthy volunteers. This was an open-label study carried out before and after administration of 20mg oral dextro-amphetamine. Subjects also rated the subjective effects of dextro-amphetamine administration using visual analog scales (VAS). Major findings. Following dextro-amphetamine administration there was a significant increase in the concentrations of both myo-inositol and phosphomonoesters. Conclusions. These findings are in keeping with suggestions that dextro-amphetamine administration increases the activity of the phosphoinositol cycle, probably via an indirect release of dopamine and noradrenaline. These results are the first time that this has been confirmed in humans.

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Dextro-amphetamine increases phosphoinositol cycle activity in volunteers: An MRS study

Abstract

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