TY - JOUR
T1 - Dextrose Prolotherapy
T2 - A Narrative Review of Basic Science, Clinical Research, and Best Treatment Recommendations
AU - Reeves, Kenneth Dean
AU - Sit, Regina W.S.
AU - Rabago, David P.
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Prolotherapy involves the injection of nonbiologic solutions, typically at soft tissue attachments and within joint spaces, to reduce pain and improve function in painful musculoskeletal conditions. A variety of solutions have been used; dextrose prolotherapy is the most rigorously studied and is the focus of this review. Although the mechanism of action is not clearly known, it is likely to be multifactorial. Data on effectiveness for temporomandibular dysfunction are promising but insufficient for recommendations. Research on the mechanism of action and clinical effects of dextrose prolotherapy are under way.
AB - Prolotherapy involves the injection of nonbiologic solutions, typically at soft tissue attachments and within joint spaces, to reduce pain and improve function in painful musculoskeletal conditions. A variety of solutions have been used; dextrose prolotherapy is the most rigorously studied and is the focus of this review. Although the mechanism of action is not clearly known, it is likely to be multifactorial. Data on effectiveness for temporomandibular dysfunction are promising but insufficient for recommendations. Research on the mechanism of action and clinical effects of dextrose prolotherapy are under way.
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U2 - 10.1016/j.pmr.2016.06.001
DO - 10.1016/j.pmr.2016.06.001
M3 - Review article
C2 - 27788902
AN - SCOPUS:84992579425
SN - 1047-9651
VL - 27
SP - 783
EP - 823
JO - Physical Medicine and Rehabilitation Clinics of North America
JF - Physical Medicine and Rehabilitation Clinics of North America
IS - 4
ER -