Diazonamide synthesis studies: Use of negishi coupling to fashion diazonamide-related biaryls with defined axial chirality

Ken S. Feldman; Kyle J. Eastman; Guillaume Lessene

doi:10.1021/ol026694t

Diazonamide synthesis studies: Use of negishi coupling to fashion diazonamide-related biaryls with defined axial chirality

Ken S. Feldman, Kyle J. Eastman, Guillaume Lessene

Chemistry

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

(matrix presented) The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropselectivity in these biaryl systems is enforced by an sp³ stereogenic center in a lactone tether in both cases.

Original language	English (US)
Pages (from-to)	3525-3528
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	20
DOIs	https://doi.org/10.1021/ol026694t
State	Published - Oct 3 2002

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol026694t

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title = "Diazonamide synthesis studies: Use of negishi coupling to fashion diazonamide-related biaryls with defined axial chirality",

abstract = "(matrix presented) The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropselectivity in these biaryl systems is enforced by an sp3 stereogenic center in a lactone tether in both cases.",

author = "Feldman, {Ken S.} and Eastman, {Kyle J.} and Guillaume Lessene",

year = "2002",

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doi = "10.1021/ol026694t",

language = "English (US)",

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journal = "Organic Letters",

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T2 - Use of negishi coupling to fashion diazonamide-related biaryls with defined axial chirality

AU - Feldman, Ken S.

AU - Eastman, Kyle J.

AU - Lessene, Guillaume

PY - 2002/10/3

Y1 - 2002/10/3

N2 - (matrix presented) The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropselectivity in these biaryl systems is enforced by an sp3 stereogenic center in a lactone tether in both cases.

AB - (matrix presented) The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropselectivity in these biaryl systems is enforced by an sp3 stereogenic center in a lactone tether in both cases.

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JO - Organic Letters

JF - Organic Letters

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Diazonamide synthesis studies: Use of negishi coupling to fashion diazonamide-related biaryls with defined axial chirality

Abstract

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