Conjugated linoleic acid (CLA) is a naturally occurring fatty acid which has anti-carcinogenic and anti-atherogenic properties. CLA activates PPARα in liver, and shares functional similarities to ligands of PPARγ, the thiazolidinediones, which are potent insulin sensitizers. We provide the first evidence that CLA is able to normalize impaired glucose tolerance and improve hyperinsulinemia in the pre-diabetic ZDF rat. Additionally, dietary CLA increased steady state levels of aP2 mRNA in adipose tissue of fatty ZDF rats compared to controls, consistent with activation of PPARγ. The insulin sensitizing effects of CLA are due, at least in part, to activation of PPARγ since increasing levels of CLA induced a dose-dependent transactivation of PPARγ in CV-1 cells cotransfected with PPARγ and PPRE X 3-luciferase reporter construct. CLA effects on glucose tolerance and glucose homeostasis indicate that dietary CLA may prove to be an important therapy for the prevention and treatment of NIDDM.
|Original language||English (US)|
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Mar 27 1998|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology