TY - JOUR
T1 - Dietary intake of magnesium or calcium and chemotherapy-induced peripheral neuropathy in colorectal cancer patients
AU - Wesselink, Evertine
AU - Winkels, Renate M.
AU - Van Baar, Harm
AU - Geijsen, Anne J.M.R.
AU - Van Zutphen, Moniek
AU - Van Halteren, Henk K.
AU - Hansson, Bibi M.E.
AU - Radema, Sandra A.
AU - De Wilt, Johannes H.W.
AU - Kampman, Ellen
AU - Kok, Dieuwertje E.G.
N1 - Funding Information:
The authors would like to thank the co-workers from the following hospitals for their involvement in recruitment for the COLON study: Hospital Gelderse Vallei, Ede; RadboudUMC, Nijmegen; Slingeland Hospital, Doetinchem,; CanisiusWilhelmina Hospital, Nijmegen; Rijnstate Hospital, Arnhem; Gelre Hospitals, Apeldoorn/Zutphen; Hospital Bernhoven, Uden; Isala, Zwolle; ZGT, Almelo; Martini Hospital, Groningen; Admiraal de Ruyter Hospital, Goes/Vlissingen, all in The Netherlands. Sources of support: This project is sponsored by Wereld Kanker Onderzoek Fonds (WCRF-NL) & World Cancer Research Fund International (WCRF International 2014/1179); Alped’Huzes/Dutch Cancer Society (UM 2012-5653, UW 2013-5927; UW 2015-7946).
Funding Information:
Acknowledgments: The authors would like to thank the co-workers from the following hospitals for their involvement in recruitment for the COLON study: Hospital Gelderse Vallei, Ede; RadboudUMC, Nijmegen; Slingeland Hospital, Doetinchem,; Canisius Wilhelmina Hospital, Nijmegen; Rijnstate Hospital, Arnhem; Gelre Hospitals, Apeldoorn/Zutphen; Hospital Bernhoven, Uden; Isala, Zwolle; ZGT, Almelo; Martini Hospital, Groningen; Admiraal de Ruyter Hospital, Goes/Vlissingen, all in The Netherlands. Sources of support: This project is sponsored by Wereld Kanker Onderzoek Fonds (WCRF-NL) & World Cancer Research Fund International (WCRF International 2014/1179); Alped’Huzes / Dutch Cancer Society (UM 2012–5653, UW 2013–5927; UW 2015-7946).
Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/4
Y1 - 2018/4
N2 - Chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe side-effect in colorectal cancer (CRC) patients. This study assessed the association between habitual dietary intake of magnesium or calcium and prevalence and severity of chronic CIPN in CRC patients receiving adjuvant chemotherapy. For this prospective cohort study, 196 CRC patients were considered. Magnesium and calcium intake was determined using a food frequency questionnaire at diagnosis, during and after chemotherapy. Chronic CIPN was assessed 12 months after diagnosis using the quality of life questionnaire CIPN20. Prevalence ratios were calculated to assess the association between magnesium or calcium intake and the prevalence of CIPN. Multivariable linear regression analysis was used to assess the association between magnesium or calcium intake and severity of CIPN. CIPN was reported by 160 (82%) patients. Magnesium intake during chemotherapy was statistically significantly associated with lower prevalence of CIPN (prevalence ratio (PR) 0.53, 95% confidence interval (CI) 0.32, 0.92). Furthermore, higher dietary intake of magnesium during (β-1.08, 95% CI -1.95, -0.22) and after chemotherapy (β-0.93, 95% CI -1.81, -0.06) was associated with less severe CIPN. No associations were found for calcium intake and the prevalence and severity of CIPN. To conclude, we observed an association between higher dietary magnesium intake and lower prevalence and severity of CIPN in CRC patients.
AB - Chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe side-effect in colorectal cancer (CRC) patients. This study assessed the association between habitual dietary intake of magnesium or calcium and prevalence and severity of chronic CIPN in CRC patients receiving adjuvant chemotherapy. For this prospective cohort study, 196 CRC patients were considered. Magnesium and calcium intake was determined using a food frequency questionnaire at diagnosis, during and after chemotherapy. Chronic CIPN was assessed 12 months after diagnosis using the quality of life questionnaire CIPN20. Prevalence ratios were calculated to assess the association between magnesium or calcium intake and the prevalence of CIPN. Multivariable linear regression analysis was used to assess the association between magnesium or calcium intake and severity of CIPN. CIPN was reported by 160 (82%) patients. Magnesium intake during chemotherapy was statistically significantly associated with lower prevalence of CIPN (prevalence ratio (PR) 0.53, 95% confidence interval (CI) 0.32, 0.92). Furthermore, higher dietary intake of magnesium during (β-1.08, 95% CI -1.95, -0.22) and after chemotherapy (β-0.93, 95% CI -1.81, -0.06) was associated with less severe CIPN. No associations were found for calcium intake and the prevalence and severity of CIPN. To conclude, we observed an association between higher dietary magnesium intake and lower prevalence and severity of CIPN in CRC patients.
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U2 - 10.3390/nu10040398
DO - 10.3390/nu10040398
M3 - Article
C2 - 29570617
AN - SCOPUS:85044603213
SN - 2072-6643
VL - 10
JO - Nutrients
JF - Nutrients
IS - 4
M1 - 498
ER -
