Dietary Nordihydroguaiaretic Acid Increases the Life Span of the Mosquito(42389)

John P. Richie, Betty Jane Mills, Calvin A. Lang

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Our previous findings indicated that a major characteristic of aging organisms is a decrease in reducing capacity. Our objectives were to correct this impairment by administration of nordihydroguaiaretic acid (NDGA), a potent reducing agent, and to determine the effect on adult longevity of the mosquito. NDGA supplements were included in the axenic larval medium or adult diet of mosquitoes of different ages. The mean adult life spans of both sexes increased 42-64% over controls (P < 0.025), and the most effective doses were 0.001% for females and 0.005% for males. This NDGA effect was dependent on the age when feeding was initiated, since only biosynthetically active larvae and young adults were responsive. Also the effect was not due to dietary restriction. These results confirm the life span-enhancement effect of NDGA using defined conditions and establish the importance of redox status in the aging process.

Original languageEnglish (US)
Pages (from-to)81-85
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - Oct 1986

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'Dietary Nordihydroguaiaretic Acid Increases the Life Span of the Mosquito(42389)'. Together they form a unique fingerprint.

Cite this