TY - JOUR
T1 - Dietary vitamin A has both chronic and acute effects on vitamin A indices in lactating rats and their offspring
AU - Akohoue, Sylvie A.
AU - Green, Joanne Balmer
AU - Green, Michael H.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2006/1
Y1 - 2006/1
N2 - To further investigate the effect of dietary vitamin A (VA) intake on milk VA concentrations and pup VA status, female rats were fed 2 concentrations of VA [0 (n = 9) or 50 μmol/kg diet (n = 10)] during pregnancy and lactation. Plasma retinol concentrations were significantly higher (30-40%) during lactation than before pregnancy or after weaning but were not influenced by dietary VA. In rats fed VA, VA concentrations during lactation were significantly higher in milk (1.5-3 times), mammary tissue (>100%), liver (4 times), pup plasma (20-40%), and pup liver (1.1-6.7 times). In Expt. 2, when VA intake was switched on d 7 of lactation from 0 to 50 μmol/kg, milk VA concentrations (2.24 ± 0.42 μmol/L; mean ± SD, n = 6) increased signi.cantly (1.7 times) by d 9 to the same level as in rats administered 50 μmol/kg (6.04 ± 0.60 μmol/L; n = 6). When VA was removed from the diet on d 7, concentrations declined significantly (by 50%) and by d 11 were the same as those in rats given 0 μmol/kg. We conclude that the rapid effect of changes in dietary VA intake are attributable to changes in the delivery of chylomicron VA to mammary tissue and milk.
AB - To further investigate the effect of dietary vitamin A (VA) intake on milk VA concentrations and pup VA status, female rats were fed 2 concentrations of VA [0 (n = 9) or 50 μmol/kg diet (n = 10)] during pregnancy and lactation. Plasma retinol concentrations were significantly higher (30-40%) during lactation than before pregnancy or after weaning but were not influenced by dietary VA. In rats fed VA, VA concentrations during lactation were significantly higher in milk (1.5-3 times), mammary tissue (>100%), liver (4 times), pup plasma (20-40%), and pup liver (1.1-6.7 times). In Expt. 2, when VA intake was switched on d 7 of lactation from 0 to 50 μmol/kg, milk VA concentrations (2.24 ± 0.42 μmol/L; mean ± SD, n = 6) increased signi.cantly (1.7 times) by d 9 to the same level as in rats administered 50 μmol/kg (6.04 ± 0.60 μmol/L; n = 6). When VA was removed from the diet on d 7, concentrations declined significantly (by 50%) and by d 11 were the same as those in rats given 0 μmol/kg. We conclude that the rapid effect of changes in dietary VA intake are attributable to changes in the delivery of chylomicron VA to mammary tissue and milk.
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U2 - 10.1093/jn/136.1.128
DO - 10.1093/jn/136.1.128
M3 - Article
C2 - 16365071
AN - SCOPUS:31544475905
SN - 0022-3166
VL - 136
SP - 128
EP - 132
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 1
ER -