Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate

Marie Claude Clemencet; Giuliana Muzio; Antonella Trombetta; Jeffrey M. Peters; Frank J. Gonzalez; Rosa A. Canuto; Norbert Latruffe

doi:10.1016/j.canlet.2004.09.016

Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate

Marie Claude Clemencet, Giuliana Muzio, Antonella Trombetta, Jeffrey M. Peters, Frank J. Gonzalez, Rosa A. Canuto, Norbert Latruffe

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8 Scopus citations

Abstract

Humans appear to be refractory to some effects of peroxisome proliferators including alterations in cell proliferation, whereas rodents are susceptible. In this study, differences between the human and rat response to peroxisome proliferators were evaluated using rat and human tumour liver cell lines. Rat 7777 cells were more responsive than human HepG2 cells to ciprofibrate as they exhibited a higher decrease in cell number than HepG2, and underwent apoptosis. Results from these studies reveal a surprising response in tumour cell lines as the typical in vivo response of increased cell proliferation and reduced apoptosis was not observed in rat tumour cell lines at concentrations greater than those used to elicit the former response.

Original language	English (US)
Pages (from-to)	217-226
Number of pages	10
Journal	Cancer Letters
Volume	222
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2004.09.016
State	Published - May 26 2005

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/j.canlet.2004.09.016

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@article{de29cf19315b4d799873ed0c134b2b1c,

title = "Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate",

abstract = "Humans appear to be refractory to some effects of peroxisome proliferators including alterations in cell proliferation, whereas rodents are susceptible. In this study, differences between the human and rat response to peroxisome proliferators were evaluated using rat and human tumour liver cell lines. Rat 7777 cells were more responsive than human HepG2 cells to ciprofibrate as they exhibited a higher decrease in cell number than HepG2, and underwent apoptosis. Results from these studies reveal a surprising response in tumour cell lines as the typical in vivo response of increased cell proliferation and reduced apoptosis was not observed in rat tumour cell lines at concentrations greater than those used to elicit the former response.",

author = "Clemencet, {Marie Claude} and Giuliana Muzio and Antonella Trombetta and Peters, {Jeffrey M.} and Gonzalez, {Frank J.} and Canuto, {Rosa A.} and Norbert Latruffe",

note = "Funding Information: We thank the {\textquoteleft}Ligue Bourguignonne contre le Cancer{\textquoteright} for its continuous support, the CNRS-GDR no. 2583 on peroxisomes, IFR no. 92, Dr P. Passilly-Degrace, Dijon for cell cultures and Prof J.K. Reddy, Northwestern University, Dept of Pathology, Chicago, USA for his advice and information on the AOX-null mice. This study was also supported by grants from the Italian Ministry for University, Scientific and Technological Research (60% and Cofinanziamento 1999, Compagnia San Paolo, Torino).",

year = "2005",

month = may,

day = "26",

doi = "10.1016/j.canlet.2004.09.016",

language = "English (US)",

volume = "222",

pages = "217--226",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate

AU - Clemencet, Marie Claude

AU - Muzio, Giuliana

AU - Trombetta, Antonella

AU - Peters, Jeffrey M.

AU - Gonzalez, Frank J.

AU - Canuto, Rosa A.

AU - Latruffe, Norbert

N1 - Funding Information: We thank the ‘Ligue Bourguignonne contre le Cancer’ for its continuous support, the CNRS-GDR no. 2583 on peroxisomes, IFR no. 92, Dr P. Passilly-Degrace, Dijon for cell cultures and Prof J.K. Reddy, Northwestern University, Dept of Pathology, Chicago, USA for his advice and information on the AOX-null mice. This study was also supported by grants from the Italian Ministry for University, Scientific and Technological Research (60% and Cofinanziamento 1999, Compagnia San Paolo, Torino).

PY - 2005/5/26

Y1 - 2005/5/26

N2 - Humans appear to be refractory to some effects of peroxisome proliferators including alterations in cell proliferation, whereas rodents are susceptible. In this study, differences between the human and rat response to peroxisome proliferators were evaluated using rat and human tumour liver cell lines. Rat 7777 cells were more responsive than human HepG2 cells to ciprofibrate as they exhibited a higher decrease in cell number than HepG2, and underwent apoptosis. Results from these studies reveal a surprising response in tumour cell lines as the typical in vivo response of increased cell proliferation and reduced apoptosis was not observed in rat tumour cell lines at concentrations greater than those used to elicit the former response.

AB - Humans appear to be refractory to some effects of peroxisome proliferators including alterations in cell proliferation, whereas rodents are susceptible. In this study, differences between the human and rat response to peroxisome proliferators were evaluated using rat and human tumour liver cell lines. Rat 7777 cells were more responsive than human HepG2 cells to ciprofibrate as they exhibited a higher decrease in cell number than HepG2, and underwent apoptosis. Results from these studies reveal a surprising response in tumour cell lines as the typical in vivo response of increased cell proliferation and reduced apoptosis was not observed in rat tumour cell lines at concentrations greater than those used to elicit the former response.

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SN - 0304-3835

VL - 222

SP - 217

EP - 226

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate

Abstract

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