TY - JOUR
T1 - Different effects of CCK antagonists on gastric-acid response to CCK and pentagastrin
AU - Corwin, R. L.
AU - Smith, G. P.
N1 - Funding Information:
We thank Richard D. Shindledecker for statistical advice, Catherine Walsh for technical assistance, and Dacie R. Lewis for surgical instruction. This study was supported by Grant MH40010, RSA MH00149, and by T32 MH18390.
PY - 1993
Y1 - 1993
N2 - The role of CCK receptor subtypes in peptide-stimulated acid secretion was assessed in six unanesthetized rats. The CCK-stimulated acid secretion was not blocked by L-365,260, a CCKB/gastrin receptor antagonist, and was significantly increased by devazepide, a CCKA receptor antagonist, give alone or together with L-365,260. L-365,260, but not devazepide, blocked pentagastrin-stimulated acid secretion, and, when given together, devazepide abolished the effect of L-365,260. We conclude: 1) pentagastrin stimulates acid secretion through a gastrin-type receptor, but CCK may not, and 2) pentagastrin and CCK can stimulate acid secretion despite simultaneous blockade of CCKB/gastrin and CCKA receptors.
AB - The role of CCK receptor subtypes in peptide-stimulated acid secretion was assessed in six unanesthetized rats. The CCK-stimulated acid secretion was not blocked by L-365,260, a CCKB/gastrin receptor antagonist, and was significantly increased by devazepide, a CCKA receptor antagonist, give alone or together with L-365,260. L-365,260, but not devazepide, blocked pentagastrin-stimulated acid secretion, and, when given together, devazepide abolished the effect of L-365,260. We conclude: 1) pentagastrin stimulates acid secretion through a gastrin-type receptor, but CCK may not, and 2) pentagastrin and CCK can stimulate acid secretion despite simultaneous blockade of CCKB/gastrin and CCKA receptors.
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U2 - 10.1016/0196-9781(93)90038-I
DO - 10.1016/0196-9781(93)90038-I
M3 - Article
C2 - 8483804
AN - SCOPUS:0027447483
SN - 0196-9781
VL - 14
SP - 253
EP - 257
JO - Peptides
JF - Peptides
IS - 2
ER -