Different effects of CCK antagonists on gastric-acid response to CCK and pentagastrin

R. L. Corwin; G. P. Smith

doi:10.1016/0196-9781(93)90038-I

Different effects of CCK antagonists on gastric-acid response to CCK and pentagastrin

R. L. Corwin
, G. P. Smith

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The role of CCK receptor subtypes in peptide-stimulated acid secretion was assessed in six unanesthetized rats. The CCK-stimulated acid secretion was not blocked by L-365,260, a CCK_B/gastrin receptor antagonist, and was significantly increased by devazepide, a CCK_A receptor antagonist, give alone or together with L-365,260. L-365,260, but not devazepide, blocked pentagastrin-stimulated acid secretion, and, when given together, devazepide abolished the effect of L-365,260. We conclude: 1) pentagastrin stimulates acid secretion through a gastrin-type receptor, but CCK may not, and 2) pentagastrin and CCK can stimulate acid secretion despite simultaneous blockade of CCK_B/gastrin and CCK_A receptors.

Original language	English (US)
Pages (from-to)	253-257
Number of pages	5
Journal	Peptides
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/0196-9781(93)90038-I
State	Published - 1993

All Science Journal Classification (ASJC) codes

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(93)90038-I

Cite this

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title = "Different effects of CCK antagonists on gastric-acid response to CCK and pentagastrin",

abstract = "The role of CCK receptor subtypes in peptide-stimulated acid secretion was assessed in six unanesthetized rats. The CCK-stimulated acid secretion was not blocked by L-365,260, a CCKB/gastrin receptor antagonist, and was significantly increased by devazepide, a CCKA receptor antagonist, give alone or together with L-365,260. L-365,260, but not devazepide, blocked pentagastrin-stimulated acid secretion, and, when given together, devazepide abolished the effect of L-365,260. We conclude: 1) pentagastrin stimulates acid secretion through a gastrin-type receptor, but CCK may not, and 2) pentagastrin and CCK can stimulate acid secretion despite simultaneous blockade of CCKB/gastrin and CCKA receptors.",

author = "Corwin, \{R. L.\} and Smith, \{G. P.\}",

note = "Funding Information: We thank Richard D. Shindledecker for statistical advice, Catherine Walsh for technical assistance, and Dacie R. Lewis for surgical instruction. This study was supported by Grant MH40010, RSA MH00149, and by T32 MH18390.",

year = "1993",

doi = "10.1016/0196-9781(93)90038-I",

language = "English (US)",

volume = "14",

pages = "253--257",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "2",

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TY - JOUR

T1 - Different effects of CCK antagonists on gastric-acid response to CCK and pentagastrin

AU - Corwin, R. L.

AU - Smith, G. P.

N1 - Funding Information: We thank Richard D. Shindledecker for statistical advice, Catherine Walsh for technical assistance, and Dacie R. Lewis for surgical instruction. This study was supported by Grant MH40010, RSA MH00149, and by T32 MH18390.

PY - 1993

Y1 - 1993

N2 - The role of CCK receptor subtypes in peptide-stimulated acid secretion was assessed in six unanesthetized rats. The CCK-stimulated acid secretion was not blocked by L-365,260, a CCKB/gastrin receptor antagonist, and was significantly increased by devazepide, a CCKA receptor antagonist, give alone or together with L-365,260. L-365,260, but not devazepide, blocked pentagastrin-stimulated acid secretion, and, when given together, devazepide abolished the effect of L-365,260. We conclude: 1) pentagastrin stimulates acid secretion through a gastrin-type receptor, but CCK may not, and 2) pentagastrin and CCK can stimulate acid secretion despite simultaneous blockade of CCKB/gastrin and CCKA receptors.

AB - The role of CCK receptor subtypes in peptide-stimulated acid secretion was assessed in six unanesthetized rats. The CCK-stimulated acid secretion was not blocked by L-365,260, a CCKB/gastrin receptor antagonist, and was significantly increased by devazepide, a CCKA receptor antagonist, give alone or together with L-365,260. L-365,260, but not devazepide, blocked pentagastrin-stimulated acid secretion, and, when given together, devazepide abolished the effect of L-365,260. We conclude: 1) pentagastrin stimulates acid secretion through a gastrin-type receptor, but CCK may not, and 2) pentagastrin and CCK can stimulate acid secretion despite simultaneous blockade of CCKB/gastrin and CCKA receptors.

UR - https://www.scopus.com/pages/publications/0027447483

UR - https://www.scopus.com/pages/publications/0027447483#tab=citedBy

U2 - 10.1016/0196-9781(93)90038-I

DO - 10.1016/0196-9781(93)90038-I

M3 - Article

C2 - 8483804

AN - SCOPUS:0027447483

SN - 0196-9781

VL - 14

SP - 253

EP - 257

JO - Peptides

JF - Peptides

IS - 2

ER -

Different effects of CCK antagonists on gastric-acid response to CCK and pentagastrin

Abstract

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