TY - JOUR
T1 - Differential antibody responses to Plasmodium falciparum glycosylphosphatidylinositol anchors in patients with cerebral and mild malaria
AU - Perraut, Ronald
AU - Diatta, Bacary
AU - Marrama, Laurence
AU - Garraud, Olivier
AU - Jambou, Ronan
AU - Longacre, Shirley
AU - Krishnegowda, Gowdahalli
AU - Dieye, Alioune
AU - Gowda, D. Channe
N1 - Funding Information:
The authors are grateful to Drs. O Mercereau Puijalon (Institut Pasteur, Paris) A. Tall, and P. Nabeth (Institut Pasteur, Dakar) for constant and helpful support. The authors acknowledge B. Diouf for expert technical assistance, Dr. T. Ka, Dr. B. Mbengue and Dr. R. Kane (Institut Pasteur, Dakar) for managing samples from hospitals. This work has supported in part by funding from the French Ministry of Cooperation and Development and from the Institut Pasteur, Paris.
PY - 2005/4
Y1 - 2005/4
N2 - Glycosylphosphatidylinositol (GPI) membrane anchors of Plasmodium falciparum surface proteins are thought to be important factors contributing to malaria pathogenesis, and anti-GPI antibodies have been suggested to provide protection by neutralizing the toxic activity of GPIs. In this study, IgG responses against P. falciparum GPIs and a baculovirus recombinant MSP1p19 antigen were evaluated in two distinct groups of 70 patients each, who were hospitalized with malaria. Anti-GPI IgGs were significantly lower in patients hospitalized with confirmed cerebral malaria compared to those with mild malaria (P < 0.01) but did not discriminate for fatal outcome. In contrast, a specific marker of the anti-parasite immunity, as monitored by the anti-MSP1p19 IgG response, was similar in both cerebral and mild malaria individuals, although it was significantly lower in a subgroup with fatal outcomes. These results are consistent with a potential anti-toxin role for anti-GPI antibodies associated with protection against cerebral malaria.
AB - Glycosylphosphatidylinositol (GPI) membrane anchors of Plasmodium falciparum surface proteins are thought to be important factors contributing to malaria pathogenesis, and anti-GPI antibodies have been suggested to provide protection by neutralizing the toxic activity of GPIs. In this study, IgG responses against P. falciparum GPIs and a baculovirus recombinant MSP1p19 antigen were evaluated in two distinct groups of 70 patients each, who were hospitalized with malaria. Anti-GPI IgGs were significantly lower in patients hospitalized with confirmed cerebral malaria compared to those with mild malaria (P < 0.01) but did not discriminate for fatal outcome. In contrast, a specific marker of the anti-parasite immunity, as monitored by the anti-MSP1p19 IgG response, was similar in both cerebral and mild malaria individuals, although it was significantly lower in a subgroup with fatal outcomes. These results are consistent with a potential anti-toxin role for anti-GPI antibodies associated with protection against cerebral malaria.
UR - https://www.scopus.com/pages/publications/19344365599
UR - https://www.scopus.com/pages/publications/19344365599#tab=citedBy
U2 - 10.1016/j.micinf.2005.01.002
DO - 10.1016/j.micinf.2005.01.002
M3 - Article
C2 - 15848275
AN - SCOPUS:19344365599
SN - 1286-4579
VL - 7
SP - 682
EP - 687
JO - Microbes and Infection
JF - Microbes and Infection
IS - 4
ER -