TY - JOUR
T1 - Differential immunometabolic responses to Delta and Omicron SARS-CoV-2 variants in golden syrian hamsters
AU - Rajaiah, Rajesh
AU - Pandey, Kabita
AU - Acharya, Arpan
AU - Ambikan, Anoop
AU - Kumar, Narendra
AU - Guda, Reema
AU - Avedissian, Sean N.
AU - Montaner, Luis J.
AU - Cohen, Samuel M.
AU - Neogi, Ujjwal
AU - Byrareddy, Siddappa N.
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/8/16
Y1 - 2024/8/16
N2 - Delta (B.1.617.2) and Omicron (B.1.1.529) variants of SARS-CoV-2 represents unique clinical characteristics. However, their role in altering immunometabolic regulations during acute infection remains convoluted. Here, we evaluated the differential immunopathogenesis of Delta vs. Omicron variants in Golden Syrian hamsters (GSH). The Delta variant resulted in higher virus titers in throat swabs and the lungs and exhibited higher lung damage with immune cell infiltration than the Omicron variant. The gene expression levels of immune mediators and metabolic enzymes, Arg-1 and IDO1 in the Delta-infected lungs were significantly higher compared to Omicron. Further, Delta/Omicron infection perturbed carbohydrates, amino acids, nucleotides, and TCA cycle metabolites and was differentially regulated compared to uninfected lungs. Collectively, our data provide a novel insight into immunometabolic/pathogenic outcomes for Delta vs. Omicron infection in the GSH displaying concordance with COVID-19 patients associated with inflammation and tissue injury during acute infection that offered possible new targets to develop potential therapeutics.
AB - Delta (B.1.617.2) and Omicron (B.1.1.529) variants of SARS-CoV-2 represents unique clinical characteristics. However, their role in altering immunometabolic regulations during acute infection remains convoluted. Here, we evaluated the differential immunopathogenesis of Delta vs. Omicron variants in Golden Syrian hamsters (GSH). The Delta variant resulted in higher virus titers in throat swabs and the lungs and exhibited higher lung damage with immune cell infiltration than the Omicron variant. The gene expression levels of immune mediators and metabolic enzymes, Arg-1 and IDO1 in the Delta-infected lungs were significantly higher compared to Omicron. Further, Delta/Omicron infection perturbed carbohydrates, amino acids, nucleotides, and TCA cycle metabolites and was differentially regulated compared to uninfected lungs. Collectively, our data provide a novel insight into immunometabolic/pathogenic outcomes for Delta vs. Omicron infection in the GSH displaying concordance with COVID-19 patients associated with inflammation and tissue injury during acute infection that offered possible new targets to develop potential therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=85199347896&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85199347896&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2024.110501
DO - 10.1016/j.isci.2024.110501
M3 - Article
C2 - 39171289
AN - SCOPUS:85199347896
SN - 2589-0042
VL - 27
JO - iScience
JF - iScience
IS - 8
M1 - 110501
ER -