Differential magnetic catch and release: Experimental parameters for controlled separation of magnetic nanoparticles

Jacob S. Beveridge, Jason R. Stephens, Mary Elizabeth Williams

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Differential magnetic catch and release (DMCR) has been used as a method for the purification and separation of magnetic nanoparticles. DMCR separates nanoparticles in the mobile phase by magnetic trapping of magnetic nanoparticles against the wall of an open tubular capillary wrapped between two narrowly spaced electromagnetic poles. Using Au and CoFe2O4 nanoparticles as model systems, the loading capacity of the 250 μm diameter capillary is determined to be ∼130 μg, and is scalable to higher quantities with larger bore capillary. Peak resolution in DMCR is externally controlled by selection of the release time (Rt) at which the magnetic flux density is removed, however, longer capture times are shown to reduce the capture yield. In addition, the magnetic nanoparticle capture yields are observed to depend on the nanoparticle diameter, mobile phase viscosity and velocity, and applied magnetic flux. Using these optimized parameters, three samples of CoFe2O4 nanoparticles whose diameters are different by less than 10 nm are separated with excellent resolution and capture yield, demonstrating the capability of DMCR for separation and purification of magnetic nanoparticles.

Original languageEnglish (US)
Pages (from-to)2564-2571
Number of pages8
Issue number12
StatePublished - Jun 21 2011

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry


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