Differential patterns of response in patients with rheumatoid arthritis following administration of an anti-CD5 immunoconjugate

V. Strand; M. L. Lee; P. Lipsky; G. Cannon; L. Calabrese; C. Wiesenhutter; S. B. Cohen; R. Fleischmann; Nancy Olsen; F. Wolfe; R. M. Karr; G. Krick; T. Medsger; W. F.C. Rigby; D. A. Fox; T. Swartz; C. V. Multz; M. Weisman

Differential patterns of response in patients with rheumatoid arthritis following administration of an anti-CD5 immunoconjugate

V. Strand, M. L. Lee, P. Lipsky, G. Cannon, L. Calabrese, C. Wiesenhutter, S. B. Cohen, R. Fleischmann, Nancy Olsen, F. Wolfe, R. M. Karr, G. Krick, T. Medsger, W. F.C. Rigby, D. A. Fox, T. Swartz, C. V. Multz, M. Weisman

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3 Scopus citations

Abstract

As part of the clinical investigation of a new biologic agent in the treatment of rheumatoid arthritis (RA) various outcome measures were utilized to evaluate clinical activity in two multicenter open label protocols. These measures included the single criteria of joint tenderness and swelling counts and scores and composite criteria based on the Paulus analysis of four placebo-controlled CSSRD studies of second line agents in RA. Findings suggest a difference in the pattern of response between early and long-standing RA. Changes in both the swollen and tender joint counts should be utilized, especially in a population with sustained disease.

Original language	English (US)
Journal	Clinical and Experimental Rheumatology
Volume	11
Issue number	SUPPL. 8
State	Published - Jan 1 1993

All Science Journal Classification (ASJC) codes

Rheumatology
Immunology and Allergy
Immunology

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Strand, V., Lee, M. L., Lipsky, P., Cannon, G., Calabrese, L., Wiesenhutter, C., Cohen, S. B., Fleischmann, R., Olsen, N., Wolfe, F., Karr, R. M., Krick, G., Medsger, T., Rigby, W. F. C., Fox, D. A., Swartz, T., Multz, C. V., & Weisman, M. (1993). Differential patterns of response in patients with rheumatoid arthritis following administration of an anti-CD5 immunoconjugate. Clinical and Experimental Rheumatology, 11(SUPPL. 8).

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title = "Differential patterns of response in patients with rheumatoid arthritis following administration of an anti-CD5 immunoconjugate",

abstract = "As part of the clinical investigation of a new biologic agent in the treatment of rheumatoid arthritis (RA) various outcome measures were utilized to evaluate clinical activity in two multicenter open label protocols. These measures included the single criteria of joint tenderness and swelling counts and scores and composite criteria based on the Paulus analysis of four placebo-controlled CSSRD studies of second line agents in RA. Findings suggest a difference in the pattern of response between early and long-standing RA. Changes in both the swollen and tender joint counts should be utilized, especially in a population with sustained disease.",

author = "V. Strand and Lee, {M. L.} and P. Lipsky and G. Cannon and L. Calabrese and C. Wiesenhutter and Cohen, {S. B.} and R. Fleischmann and Nancy Olsen and F. Wolfe and Karr, {R. M.} and G. Krick and T. Medsger and Rigby, {W. F.C.} and Fox, {D. A.} and T. Swartz and Multz, {C. V.} and M. Weisman",

year = "1993",

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language = "English (US)",

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Strand, V, Lee, ML, Lipsky, P, Cannon, G, Calabrese, L, Wiesenhutter, C, Cohen, SB, Fleischmann, R, Olsen, N, Wolfe, F, Karr, RM, Krick, G, Medsger, T, Rigby, WFC, Fox, DA, Swartz, T, Multz, CV & Weisman, M 1993, 'Differential patterns of response in patients with rheumatoid arthritis following administration of an anti-CD5 immunoconjugate', Clinical and Experimental Rheumatology, vol. 11, no. SUPPL. 8.

TY - JOUR

T1 - Differential patterns of response in patients with rheumatoid arthritis following administration of an anti-CD5 immunoconjugate

AU - Strand, V.

AU - Lee, M. L.

AU - Lipsky, P.

AU - Cannon, G.

AU - Calabrese, L.

AU - Wiesenhutter, C.

AU - Cohen, S. B.

AU - Fleischmann, R.

AU - Olsen, Nancy

AU - Wolfe, F.

AU - Karr, R. M.

AU - Krick, G.

AU - Medsger, T.

AU - Rigby, W. F.C.

AU - Fox, D. A.

AU - Swartz, T.

AU - Multz, C. V.

AU - Weisman, M.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - As part of the clinical investigation of a new biologic agent in the treatment of rheumatoid arthritis (RA) various outcome measures were utilized to evaluate clinical activity in two multicenter open label protocols. These measures included the single criteria of joint tenderness and swelling counts and scores and composite criteria based on the Paulus analysis of four placebo-controlled CSSRD studies of second line agents in RA. Findings suggest a difference in the pattern of response between early and long-standing RA. Changes in both the swollen and tender joint counts should be utilized, especially in a population with sustained disease.

AB - As part of the clinical investigation of a new biologic agent in the treatment of rheumatoid arthritis (RA) various outcome measures were utilized to evaluate clinical activity in two multicenter open label protocols. These measures included the single criteria of joint tenderness and swelling counts and scores and composite criteria based on the Paulus analysis of four placebo-controlled CSSRD studies of second line agents in RA. Findings suggest a difference in the pattern of response between early and long-standing RA. Changes in both the swollen and tender joint counts should be utilized, especially in a population with sustained disease.

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M3 - Article

C2 - 7686831

AN - SCOPUS:0027155389

SN - 0392-856X

VL - 11

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

IS - SUPPL. 8

ER -

Differential patterns of response in patients with rheumatoid arthritis following administration of an anti-CD5 immunoconjugate

Abstract

All Science Journal Classification (ASJC) codes

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