TY - JOUR
T1 - Diffuse large B-cell lymphoma with coexpression of CD3 in a pediatric patient
T2 - A case report, review of the literature, and tissue microarray study
AU - Wallentine, Jeremy C.
AU - Perkins, Sherrie L.
AU - Tripp, Sheryl R.
AU - Bruggman, Richard D.
AU - Bayerl, Michael G.
PY - 2009/2
Y1 - 2009/2
N2 - The aberrant expression of T-cell antigens on B-cell-derived non-Hodgkin lymphomas has been described. However, the expression of the lineage-specific T-cell antigen, CD3, in hematologic malignancies is exceedingly rare and to the best of our knowledge has not been reported in pediatric patients. Here we describe the first case of a CD3+ diffuse large B-cell lymphoma in a 9-year-old male patient that is well documented by immunohistochemistry. In addition, results of a tissue microarray study composed of B-cell-derived non-Hodgkin lymphomas (n=77) and reactive lymphoid hyperplasia (n=13) dual stained for PAX5/CD3 are also reported.
AB - The aberrant expression of T-cell antigens on B-cell-derived non-Hodgkin lymphomas has been described. However, the expression of the lineage-specific T-cell antigen, CD3, in hematologic malignancies is exceedingly rare and to the best of our knowledge has not been reported in pediatric patients. Here we describe the first case of a CD3+ diffuse large B-cell lymphoma in a 9-year-old male patient that is well documented by immunohistochemistry. In addition, results of a tissue microarray study composed of B-cell-derived non-Hodgkin lymphomas (n=77) and reactive lymphoid hyperplasia (n=13) dual stained for PAX5/CD3 are also reported.
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U2 - 10.1097/MPH.0b013e31818b354a
DO - 10.1097/MPH.0b013e31818b354a
M3 - Article
C2 - 19194198
AN - SCOPUS:60849132503
SN - 1077-4114
VL - 31
SP - 124
EP - 127
JO - Journal of pediatric hematology/oncology
JF - Journal of pediatric hematology/oncology
IS - 2
ER -