Diffusion-controlled polymer dissolution and drug release

J. S. Vrentas; C. M. Vrentas

doi:10.1002/app.20406

Diffusion-controlled polymer dissolution and drug release

J. S. Vrentas, C. M. Vrentas

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A model is formulated for diffusion-controlled polymer dissolution and simultaneous drug release for amorphous, uncrosslinked polymers. Calculated fractional drug release versus time curves are similar to experimental curves reported in the literature. Solutions of the transport equations provide a way of illustrating how polymer type and molecular weight can be used in an attempt to approach a constant drug release rate.

Original language	English (US)
Pages (from-to)	92-99
Number of pages	8
Journal	Journal of Applied Polymer Science
Volume	93
Issue number	1
DOIs	https://doi.org/10.1002/app.20406
State	Published - Jul 5 2004

All Science Journal Classification (ASJC) codes

General Chemistry
Surfaces, Coatings and Films
Polymers and Plastics
Materials Chemistry

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10.1002/app.20406

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abstract = "A model is formulated for diffusion-controlled polymer dissolution and simultaneous drug release for amorphous, uncrosslinked polymers. Calculated fractional drug release versus time curves are similar to experimental curves reported in the literature. Solutions of the transport equations provide a way of illustrating how polymer type and molecular weight can be used in an attempt to approach a constant drug release rate.",

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AB - A model is formulated for diffusion-controlled polymer dissolution and simultaneous drug release for amorphous, uncrosslinked polymers. Calculated fractional drug release versus time curves are similar to experimental curves reported in the literature. Solutions of the transport equations provide a way of illustrating how polymer type and molecular weight can be used in an attempt to approach a constant drug release rate.

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Diffusion-controlled polymer dissolution and drug release

Abstract

All Science Journal Classification (ASJC) codes

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