TY - JOUR
T1 - Diffusive and convective solute transport through hemodialysis membranes
T2 - A hydrodynamic analysis
AU - Langsdorf, Leah J.
AU - Zydney, Andrew L.
PY - 1994/5
Y1 - 1994/5
N2 - Recent clinical studies have shown that the overall effectiveness of hemodialysis is determined by both the convective and diffusive transport of a wide range of different molecular weight solutes. In this study, transport data were obtained for vitamin B12 and for polydisperse dextrans with a wide range of molecular weights using flat sheet Cuprophan and AN69 polyacrylonitrile membranes. The flux dependence of the actual sieving coefficient was described using classical membrane transport theory, allowing accurate measurements of both the diffusive and convective contributions to the overall solute transport through the porous structure of these dialysis membranes. Asymptotic membrane sieving coefficients and hindered diffusivities were in good agreement with a hydrodynamic model that accounts for the membrane pore size distribution through an expression for the solute partition coefficient in a random porous medium. This model provides an accurate quantitative description of both solute diffusion and convection through hemodialysis membranes, which is critical for the effective design and operation of hemodialyzers. © 1994 John Wiley & Sons, Inc.
AB - Recent clinical studies have shown that the overall effectiveness of hemodialysis is determined by both the convective and diffusive transport of a wide range of different molecular weight solutes. In this study, transport data were obtained for vitamin B12 and for polydisperse dextrans with a wide range of molecular weights using flat sheet Cuprophan and AN69 polyacrylonitrile membranes. The flux dependence of the actual sieving coefficient was described using classical membrane transport theory, allowing accurate measurements of both the diffusive and convective contributions to the overall solute transport through the porous structure of these dialysis membranes. Asymptotic membrane sieving coefficients and hindered diffusivities were in good agreement with a hydrodynamic model that accounts for the membrane pore size distribution through an expression for the solute partition coefficient in a random porous medium. This model provides an accurate quantitative description of both solute diffusion and convection through hemodialysis membranes, which is critical for the effective design and operation of hemodialyzers. © 1994 John Wiley & Sons, Inc.
UR - http://www.scopus.com/inward/record.url?scp=0028436433&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028436433&partnerID=8YFLogxK
U2 - 10.1002/jbm.820280507
DO - 10.1002/jbm.820280507
M3 - Article
C2 - 7517941
AN - SCOPUS:0028436433
SN - 0021-9304
VL - 28
SP - 573
EP - 582
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
IS - 5
ER -