Direct inhibiton of tyrosine hydroxylase activity by catechol estrogens

Thomas Lloyd, Judith Weisz

Research output: Contribution to journalArticlepeer-review

141 Scopus citations


Catechol estrogens, the 2-hydroxylated metabolites of estrogens, recently shown to be formed in brain, inhibit tyrosine hydroxylase, the enzyme that catalyzes the pivotal step in the biosynthesis of the neurotransmitters dopamine and norepinephrine. The nature of the inhibition is by competition with the pterin cofactor and thus resembles feedback inhibition of the enzyme by catecholamines.

Original languageEnglish (US)
Pages (from-to)4841-4843
Number of pages3
JournalJournal of Biological Chemistry
Issue number14
StatePublished - 1978

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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