Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America

Etienne Patin; Marie Lopez; Rebecca Grollemund; Paul Verdu; Christine Harmant; Hélène Quach; Guillaume Laval; George H. Perry; Luis B. Barreiro; Alain Froment; Evelyne Heyer; Achille Massougbodji; Cesar Fortes-Lima; Florence Migot-Nabias; Gil Bellis; Jean Michel Dugoujon; Joana B. Pereira; Verónica Fernandes; Luisa Pereira; Lolke Van Der Veen; Patrick Mouguiama-Daouda; Carlos D. Bustamante; Jean Marie Hombert; Lluís Quintana-Murci

doi:10.1126/science.aal1988

Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America

Etienne Patin, Marie Lopez, Rebecca Grollemund, Paul Verdu, Christine Harmant, Hélène Quach, Guillaume Laval, George H. Perry, Luis B. Barreiro, Alain Froment, Evelyne Heyer, Achille Massougbodji, Cesar Fortes-Lima, Florence Migot-Nabias, Gil Bellis, Jean Michel Dugoujon, Joana B. Pereira, Verónica Fernandes, Luisa Pereira, Lolke Van Der VeenPatrick Mouguiama-Daouda, Carlos D. Bustamante, Jean Marie Hombert, Lluís Quintana-Murci

Research output: Contribution to journal › Article › peer-review

160 Scopus citations

Abstract

Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-speaking populations remains largely unexplored. We generated genomic data for 1318 individuals from 35 populations in western central Africa, where Bantu languages originated. We found that early Bantu speakers first moved southward, through the equatorial rainforest, before spreading toward eastern and southern Africa. We also found that genetic adaptation of Bantu speakers was facilitated by admixture with local populations, particularly for the HLA and LCT loci. Finally, we identified a major contribution of western central African Bantu speakers to the ancestry of African Americans, whose genomes present no strong signals of natural selection. Together, these results highlight the contribution of Bantu-speaking peoples to the complex genetic history of Africans and African Americans.

Original language	English (US)
Pages (from-to)	543-546
Number of pages	4
Journal	Science
Volume	356
Issue number	6337
DOIs	https://doi.org/10.1126/science.aal1988
State	Published - May 5 2017

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Patin, E., Lopez, M., Grollemund, R., Verdu, P., Harmant, C., Quach, H., Laval, G., Perry, G. H., Barreiro, L. B., Froment, A., Heyer, E., Massougbodji, A., Fortes-Lima, C., Migot-Nabias, F., Bellis, G., Dugoujon, J. M., Pereira, J. B., Fernandes, V., Pereira, L., ... Quintana-Murci, L. (2017). Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America. Science, 356(6337), 543-546. https://doi.org/10.1126/science.aal1988

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title = "Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America",

abstract = "Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-speaking populations remains largely unexplored. We generated genomic data for 1318 individuals from 35 populations in western central Africa, where Bantu languages originated. We found that early Bantu speakers first moved southward, through the equatorial rainforest, before spreading toward eastern and southern Africa. We also found that genetic adaptation of Bantu speakers was facilitated by admixture with local populations, particularly for the HLA and LCT loci. Finally, we identified a major contribution of western central African Bantu speakers to the ancestry of African Americans, whose genomes present no strong signals of natural selection. Together, these results highlight the contribution of Bantu-speaking peoples to the complex genetic history of Africans and African Americans.",

author = "Etienne Patin and Marie Lopez and Rebecca Grollemund and Paul Verdu and Christine Harmant and H{\'e}l{\`e}ne Quach and Guillaume Laval and Perry, {George H.} and Barreiro, {Luis B.} and Alain Froment and Evelyne Heyer and Achille Massougbodji and Cesar Fortes-Lima and Florence Migot-Nabias and Gil Bellis and Dugoujon, {Jean Michel} and Pereira, {Joana B.} and Ver{\'o}nica Fernandes and Luisa Pereira and {Van Der Veen}, Lolke and Patrick Mouguiama-Daouda and Bustamante, {Carlos D.} and Hombert, {Jean Marie} and Llu{\'i}s Quintana-Murci",

year = "2017",

month = may,

day = "5",

doi = "10.1126/science.aal1988",

language = "English (US)",

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Patin, E, Lopez, M, Grollemund, R, Verdu, P, Harmant, C, Quach, H, Laval, G, Perry, GH, Barreiro, LB, Froment, A, Heyer, E, Massougbodji, A, Fortes-Lima, C, Migot-Nabias, F, Bellis, G, Dugoujon, JM, Pereira, JB, Fernandes, V, Pereira, L, Van Der Veen, L, Mouguiama-Daouda, P, Bustamante, CD, Hombert, JM & Quintana-Murci, L 2017, 'Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America', Science, vol. 356, no. 6337, pp. 543-546. https://doi.org/10.1126/science.aal1988

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AU - Patin, Etienne

AU - Lopez, Marie

AU - Grollemund, Rebecca

AU - Verdu, Paul

AU - Harmant, Christine

AU - Quach, Hélène

AU - Laval, Guillaume

AU - Perry, George H.

AU - Barreiro, Luis B.

AU - Froment, Alain

AU - Heyer, Evelyne

AU - Massougbodji, Achille

AU - Fortes-Lima, Cesar

AU - Migot-Nabias, Florence

AU - Bellis, Gil

AU - Dugoujon, Jean Michel

AU - Pereira, Joana B.

AU - Fernandes, Verónica

AU - Pereira, Luisa

AU - Van Der Veen, Lolke

AU - Mouguiama-Daouda, Patrick

AU - Bustamante, Carlos D.

AU - Hombert, Jean Marie

AU - Quintana-Murci, Lluís

PY - 2017/5/5

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AB - Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-speaking populations remains largely unexplored. We generated genomic data for 1318 individuals from 35 populations in western central Africa, where Bantu languages originated. We found that early Bantu speakers first moved southward, through the equatorial rainforest, before spreading toward eastern and southern Africa. We also found that genetic adaptation of Bantu speakers was facilitated by admixture with local populations, particularly for the HLA and LCT loci. Finally, we identified a major contribution of western central African Bantu speakers to the ancestry of African Americans, whose genomes present no strong signals of natural selection. Together, these results highlight the contribution of Bantu-speaking peoples to the complex genetic history of Africans and African Americans.

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ER -

Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America

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