Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism

Romain Villéger, Marina Chulkina, Randy C. Mifflin, Don W. Powell, Irina V. Pinchuk

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Stromal myo-/fibroblasts (MFs) account for up to 30% of lamina propria cells in the normal human colon and their number is dramatically increased in colon cancer (CRC). Fibroblasts from cancers, also known as cancer-associated fibroblasts (CAFs), differ from normal colonic MF (N-MFs) and support tumor-promoting inflammation, in part due to increased IL-6 secretion. In this research perspective, we highlight recent data obtained regarding IL-6 regulation in colorectal cancer CAFs through vitamin A (retinol) metabolism, discuss current limitations in our understanding of the mechanisms leading to the CAF pro-inflammatory phenotype, and discuss potential approaches to target CAF retinoid metabolism during CRC treatment.

Original languageEnglish (US)
Pages (from-to)377-381
Number of pages5
JournalOncotarget
Volume14
Issue number1
DOIs
StatePublished - 2023

All Science Journal Classification (ASJC) codes

  • Oncology

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