Disseminating melanoma cells surf on calcium waves

Jianwei Sun; Shengchen Lin; Tyler Keeley; Shengyu Yang

doi:10.1080/23723556.2014.1002714

Disseminating melanoma cells surf on calcium waves

Jianwei Sun, Shengchen Lin, Tyler Keeley, Shengyu Yang

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Dysregulated calcium signaling has been increasingly implicated in tumor dissemination and progression. In a recent study, we investigated the mechanism underlying calcium-mediated invasion and metastasis in melanoma and discovered that hyperactive Ca²⁺ oscillation in melanoma cells enhanced invasion and metastasis by promoting invadopodium formation and extracellular matrix remodeling.

Original language	English (US)
Article number	e1002714
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2014.1002714
State	Published - Oct 2 2015

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

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10.1080/23723556.2014.1002714

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title = "Disseminating melanoma cells surf on calcium waves",

abstract = "Dysregulated calcium signaling has been increasingly implicated in tumor dissemination and progression. In a recent study, we investigated the mechanism underlying calcium-mediated invasion and metastasis in melanoma and discovered that hyperactive Ca2+ oscillation in melanoma cells enhanced invasion and metastasis by promoting invadopodium formation and extracellular matrix remodeling.",

author = "Jianwei Sun and Shengchen Lin and Tyler Keeley and Shengyu Yang",

note = "Funding Information: This work is supported by the National Cancer Institute (R01175741). Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Jianwei Sun, Shengchen Lin, Tyler Keeley, and Shengyu Yang.",

year = "2015",

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doi = "10.1080/23723556.2014.1002714",

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T1 - Disseminating melanoma cells surf on calcium waves

AU - Sun, Jianwei

AU - Lin, Shengchen

AU - Keeley, Tyler

AU - Yang, Shengyu

N1 - Funding Information: This work is supported by the National Cancer Institute (R01175741). Publisher Copyright: © 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Jianwei Sun, Shengchen Lin, Tyler Keeley, and Shengyu Yang.

PY - 2015/10/2

Y1 - 2015/10/2

N2 - Dysregulated calcium signaling has been increasingly implicated in tumor dissemination and progression. In a recent study, we investigated the mechanism underlying calcium-mediated invasion and metastasis in melanoma and discovered that hyperactive Ca2+ oscillation in melanoma cells enhanced invasion and metastasis by promoting invadopodium formation and extracellular matrix remodeling.

AB - Dysregulated calcium signaling has been increasingly implicated in tumor dissemination and progression. In a recent study, we investigated the mechanism underlying calcium-mediated invasion and metastasis in melanoma and discovered that hyperactive Ca2+ oscillation in melanoma cells enhanced invasion and metastasis by promoting invadopodium formation and extracellular matrix remodeling.

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JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

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ER -

Disseminating melanoma cells surf on calcium waves

Abstract

All Science Journal Classification (ASJC) codes

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