TY - JOUR
T1 - Dissociation of initial trajectory and final position errors during visuomotor adaptation following unilateral stroke
AU - Schaefer, Sydney Y.
AU - Haaland, Kathleen Y.
AU - Sainburg, Robert L.
N1 - Funding Information:
This research was supported by the Department of Veterans Affairs, Merit Review Grant , and the National Institutes of Health , National Institute for Child Health and Human Development ( #RO1HD39311 ); National Institute on Aging training grant , Interdisciplinary Training in Gerontology ( #T32AG00048 ). This project was also funded, in part, under a grant with the Pennsylvania Department of Health using Tobacco Settlement Funds. The Department specifically disclaims responsibility for any analyses, interpretations or conclusions. Further acknowledgments are to 1) Jennifer Hogan, Rena Singleton, and Lee Stapp for data collection, 2) Dr. Robert Knight for MRI tracings and neuroanatomical consultation, 3) Dr. Alvaro Magalhaes for clinical neuroradiological consultation, and 4) Drs. John Adair and Sally Harris, as well as HealthSouth Rehabilitation Hospital and Lovelace Medical Center, for patient referral.
PY - 2009/10/28
Y1 - 2009/10/28
N2 - Previous studies have demonstrated that following stroke, motor impairment can occur ipsilateral to the lesion. Such impairments have provided insight into the contributions of each hemisphere to movement control, showing that left and right hemisphere damage produce different effects on movement: Left hemisphere damage produces deficits in specifying features of movement trajectory, while right hemisphere damage produces deficits in achieving an accurate and stable final position. We now propose that left and right hemisphere damage should also produce different deficits in the adaptation of trajectory and position. To test this idea, we examined adaptation to visuomotor rotations in the ipsilesional arms of hemiparetic stroke patients with left (LHD) and right hemisphere damage (RHD). We found that LHD interfered with adaptation of initial direction, but not with the ability to adapt the final position of the limb. In contrast, RHD interfered with online corrections to the final position during the course of adaptation. These findings support our hypothesis that the control of trajectory and steady-state position may be lateralized to the left and right hemispheres, respectively.
AB - Previous studies have demonstrated that following stroke, motor impairment can occur ipsilateral to the lesion. Such impairments have provided insight into the contributions of each hemisphere to movement control, showing that left and right hemisphere damage produce different effects on movement: Left hemisphere damage produces deficits in specifying features of movement trajectory, while right hemisphere damage produces deficits in achieving an accurate and stable final position. We now propose that left and right hemisphere damage should also produce different deficits in the adaptation of trajectory and position. To test this idea, we examined adaptation to visuomotor rotations in the ipsilesional arms of hemiparetic stroke patients with left (LHD) and right hemisphere damage (RHD). We found that LHD interfered with adaptation of initial direction, but not with the ability to adapt the final position of the limb. In contrast, RHD interfered with online corrections to the final position during the course of adaptation. These findings support our hypothesis that the control of trajectory and steady-state position may be lateralized to the left and right hemispheres, respectively.
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U2 - 10.1016/j.brainres.2009.08.063
DO - 10.1016/j.brainres.2009.08.063
M3 - Article
C2 - 19728993
AN - SCOPUS:71749112367
SN - 0006-8993
VL - 1298
SP - 78
EP - 91
JO - Brain research
JF - Brain research
ER -