Diversity of CRISPR-Cas immune systems and molecular machines

Rodolphe Barrangou

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations


Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.

Original languageEnglish (US)
Article number247
JournalGenome biology
Issue number1
StatePublished - Nov 9 2015

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology


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